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Literature DB >> 6251410

Proton beam irradiation. An alternative to enucleation for intraocular melanomas.

E S Gragoudas, M Goitein, L Verhey, J Munzenreider, H D Suit, A Koehler.

Abstract

Proton irradiation was used in the treatment of uveal melanomas in 36 eyes. The average follow-up period was 16 months. One patient developed metastatic disease and died. No eye has been enucleated and tumor regression has been observed in all 22 eyes with a follow-up of more than 12 months. This type of treatment offers definite advantages over previously used methods, can be used for the treatment of relatively large melanomas, and should be considered before enucleation.

Entities: Disease Species

Mesh：

Substances：
Protons

Year: 1980 PMID： 6251410 DOI： 10.1016/s0161-6420(80)35212-3

Source DB: PubMed Journal: Ophthalmology ISSN： 0161-6420 Impact factor: 12.079

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Cited

36 in total

1. A randomized, controlled trial of varying radiation doses in the treatment of choroidal melanoma.

Authors: E S Gragoudas
Journal: Trans Am Ophthalmol Soc Date: 1998

Review 2. Management of intraocular melanoma.

Authors: W S Foulds
Journal: Br J Ophthalmol Date: 1990-09 Impact factor: 4.638

3. Experimental study on the fractionation schedule for proton irradiation of uveal melanoma.

Authors: G Wollensak; L Zografos; C Perret; E Egger; H Fritz-Niggli
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1990 Impact factor: 3.117

4. Treatment of recurrent orbital haemangiopericytoma with surgery and proton beam therapy.

Authors: H C Gear; E G Kemp; A Kacperek; R D Errington
Journal: Br J Ophthalmol Date: 2005-01 Impact factor: 4.638

5. Monte Carlo calculations and measurements of absorbed dose per monitor unit for the treatment of uveal melanoma with proton therapy.

Authors: Nicholas Koch; Wayne D Newhauser; Uwe Titt; Dan Gombos; Kevin Coombes; George Starkschall
Journal: Phys Med Biol Date: 2008-02-25 Impact factor: 3.609

Proton beam irradiation. An alternative to enucleation for intraocular melanomas.

1. A randomized, controlled trial of varying radiation doses in the treatment of choroidal melanoma.

Review 2. Management of intraocular melanoma.

3. Experimental study on the fractionation schedule for proton irradiation of uveal melanoma.

4. Treatment of recurrent orbital haemangiopericytoma with surgery and proton beam therapy.

5. Monte Carlo calculations and measurements of absorbed dose per monitor unit for the treatment of uveal melanoma with proton therapy.

6. Proton therapy for uveal melanomas and other eye lesions.

7. Preliminary results of proton beam irradiation of macular and paramacular melanomas.

8. Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland.

9. Primary choroidal and cutaneous melanomas, bilateral choroidal melanomas, and familial occurrence of melanomas.

10. Treatment of juxtapapillary melanomas.