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Literature DB >> 6247896

Calcium, histamine, and pentagastrin: speculations about the regulation of gastric acid secretion at cellular level.

Abstract

The acid secretory response to acetylcholine, histamine, pentagastrin and db-cAMP was studied in dependence of serosal calcium and magnesium level in the isolated whole stomach of the mouse. Histamine- or db-cAMP-induced acid secretion from isolated stomach was not dependent on calcium. Secretory responses to pentagastrin and acetylcholine were strongly diminished in the absence of serosal calcium. Reduction of serosal magnesium concentration influenced neither histamine- nor pentagastrin-induced secretion. The calcium-antagonist verapamil reduced only acid response to pentagastrin. A working hypothesis has been discussed to understand the possible role of calcium in the regulation gastric acid secretion.

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Year: 1980 PMID： 6247896 DOI： 10.1007/bf02024209

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

9 in total

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Authors: I Szelenyi; K Thiemer
Journal: Pharmacology Date: 1979 Impact factor: 2.547

2. Are gastrin receptors located on parietal cells [proceedings]?

Authors: J W Black; L A Welch
Journal: Br J Pharmacol Date: 1977-03 Impact factor: 8.739

3. Effect of Ca2+, Mg2+, NaN3, cholinergic agents, and gastrointestinal hormones on the guanylate cyclase from guinea pig gastric mucosa.

Authors: M Griessen
Journal: Gastroenterology Date: 1978-02 Impact factor: 22.682

Review 4. Cyclic GMP and gastric acid secretion.

Authors: M S Amer
Journal: Am J Dig Dis Date: 1974-01

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Authors: R A Levine; D E Wilson
Journal: Ann N Y Acad Sci Date: 1971-12-30 Impact factor: 5.691

6. Studies on adenyl cyclase in Necturus gastric mucosa.

Authors: S Nakajima; B I Hirschowitz; G Sachs
Journal: Arch Biochem Biophys Date: 1971-03 Impact factor: 4.013

7. Comparison of gastric secretion in conscious dogs and cats.

Authors: S Emås; M I Grossman
Journal: Gastroenterology Date: 1967-01 Impact factor: 22.682

8. Production of acid secretion in the mouse isolated stomach by electrical field stimulation [proceedings].

Authors: J A Angus; J W Black
Journal: Br J Pharmacol Date: 1978-03 Impact factor: 8.739

9. The role of the alkaline earth ions in anaphylactic histamine secretion.

Authors: J C Foreman; J L Mongar
Journal: J Physiol Date: 1972-08 Impact factor: 5.182

9 in total

6 in total

4. The effect of different calcium antagonists on histamine- and carbachol-induced acid secretion in the isolated mouse stomach.

Authors: F Erjavec; L Stanovnik
Journal: Agents Actions Date: 1989-04

5. Calcium channel blockers prevent stress-induced ulcers in rats.

Authors: B C Yegen; I Alican; A S Yalçin; S Oktay
Journal: Agents Actions Date: 1992-01

6. Differential effects of calcium channel antagonists on histamine and pentagastrin-stimulated gastric acid secretion in the rat.

Authors: M Bouclier; M Spedding
Journal: Agents Actions Date: 1985-09