Literature DB >> 1509972

Calcium channel blockers prevent stress-induced ulcers in rats.

B C Yegen1, I Alican, A S Yalçin, S Oktay.   

Abstract

Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1509972     DOI： 10.1007/bf01990962

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  31 in total

1.  Calcium channel modulators: effects on gastric function.

Authors:  G B Glavin
Journal:  Eur J Pharmacol       Date:  1989-02-07       Impact factor: 4.432

Review 2.  The relationship between gastrointestinal motility and secretion.

Authors:  B Greenwood; J S Davison
Journal:  Am J Physiol       Date:  1987-01

3.  Lipid peroxidation of phosphatidylcholine liposomes depressed by the calcium channel blockers nifedipine and verapamil and by the antiarrhythmic-antihypoxic drug stobadine.

Authors:  K Ondrias; V Misík; D Gergel; A Stasko
Journal:  Biochim Biophys Acta       Date:  1989-06-28

4.  Gastric damage following local intra-arterial administration of reactive oxygen metabolites in the rat.

Authors:  J V Esplugues; B J Whittle
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

5.  Effect of verapamil on gastric secretion in man.

Authors:  E Aadland; A Berstad
Journal:  Scand J Gastroenterol       Date:  1983-10       Impact factor: 2.423

6.  Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats.

Authors:  I Szelenyi; K Brune
Journal:  Dig Dis Sci       Date:  1988-07       Impact factor: 3.199

7.  Calcium channel blockers protect against ethanol- and indomethacin-induced gastric lesions in rats.

Authors:  B I Ghanayem; H B Matthews; R R Maronpot
Journal:  Gastroenterology       Date:  1987-01       Impact factor: 22.682

8.  Calcium and stimulus-secretion coupling in gastric fundic mucosa. Effect of inhibition of calcium transport by verapamil on gastric acid secretion in the isolated guinea pig fundic mucosa and in healthy subjects.

Authors:  P Kirkegaard; J Christiansen; B Petersen; P Skov Olsen
Journal:  Scand J Gastroenterol       Date:  1982-06       Impact factor: 2.423

Review 9.  Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms.

Authors:  T A Miller
Journal:  Am J Physiol       Date:  1983-11

10.  Acetyl salicylic acid-induced gastric mucosal lesions: no role of gastric glutathione.

Authors:  B I Ghanayem; A E Ahmed; P J Boor
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1984-07
View more
  3 in total

Review 1.  Effect of psychogenic stress on gastrointestinal function.

Authors:  O Martínez-Augustín; F Sánchez de Medina; F Sánchez de Medina
Journal:  J Physiol Biochem       Date:  2000-09       Impact factor: 4.158

2.  Protective effect of excitatory amino acids on cold-restraint stress-induced gastric ulcers in mice: role of cyclic nucleotides.

Authors:  S H Chen; H L Lei; L R Huang; L H Tsai
Journal:  Dig Dis Sci       Date:  2001-10       Impact factor: 3.199

3.  Gastric histamine content and ulcer formation in rats with ethanol-induced injury. Effects of cinnarizine and flunarizine.

Authors:  V Lozeva; K Marazova; A Belcheva
Journal:  Agents Actions       Date:  1994-06
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.