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Literature DB >> 4116105

The role of the alkaline earth ions in anaphylactic histamine secretion.

Abstract

1. Anaphylactic histamine release from rat peritoneal mast cells is dependent on the presence of calcium ions. Graded increase of histamine release occurs as the calcium ion concentration is raised from 0.1 to 1.0 m-mole/l.2. Magnesium antagonizes the effect of calcium. The dissociation constant of the Mg-receptor complex was found to be 9.4 m-mole/l.3. Strontium will replace calcium ions in the activation of anaphylactic histamine release. Graded increase of histamine release occurs when the strontium ion concentration is raised from 1.0 to 10.0 m-mole/l.4. Magnesium also antagonizes the effect of strontium. The dissociation constant of the magnesium-receptor complex was found to be 11.0 m-mole/l.5. The log concentration-effect curve for strontium has a greater maximum and steeper slope than the curve for calcium.6. Measurements of the interaction of calcium and strontium ions are in agreement with the hypothesis that strontium possesses a higher efficacy but a lower affinity than calcium, for the ;calcium receptor' in mast cells.7. Barium will replace calcium in the activation of anaphylactic histamine release.

Entities: Chemical Species

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Year: 1972 PMID： 4116105 PMCID： PMC1331518 DOI： 10.1113/jphysiol.1972.sp009921

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

18 in total

1. Improved automatic apparatus for pharmacological assays on isolated preparations.

Authors: A BOURA; J L MONGAR; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1954-03

2. The effect of calcium ions on the motor end-plate potentials.

Authors: J DEL CASTILLO; L STARK
Journal: J Physiol Date: 1952-04 Impact factor: 5.182

3. Structural and functional changes of frog neuromuscular junctions in high calcium solutions.

Authors: J Heuser; B Katz; R Miledi
Journal: Proc R Soc Lond B Biol Sci Date: 1971-09-28

4. Ca++ dependence of histamine release and formation of slow reacting substance in the cat paw.

Authors: K Strandberg
Journal: Acta Physiol Scand Date: 1971-08

5. The binding of calcium at lipid-water interfaces.

Authors: H Hauser; R M Dawson
Journal: Eur J Biochem Date: 1967-03

6. Ultrastructural changes in rat mast cells during anaphylactic histamine release.

Authors: N Chakravarty; G T Gustafson; E Pihl
Journal: Acta Pathol Microbiol Scand Date: 1967

7. The mechanism of anaphylactic histamine release from rabbit leucocytes.

Authors: M W Greaves; J L Mongar
Journal: Immunology Date: 1968-11 Impact factor: 7.397

8. Some quantitative uses of drug antagonists.

Authors: O ARUNLAKSHANA; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1959-03

9. A study of the mechanism of quantal transmitter release at a chemical synapse.

Authors: Z L Blioch; I M Glagoleva; E A Liberman; V A Nenashev
Journal: J Physiol Date: 1968-11 Impact factor: 5.182

10. Strontium and quantal release of transmitter at the neuromuscular junction.

Authors: F A Dodge; R Miledi; R Rahamimoff
Journal: J Physiol Date: 1969-01 Impact factor: 5.182

83 in total

1. Na(+)-dependent Ca(2+) transport modulates the secretory response to the Fcepsilon receptor stimulus of mast cells.

Authors: E Rumpel; U Pilatus; A Mayer; I Pecht
Journal: Biophys J Date: 2000-12 Impact factor: 4.033

2. On the nature of the presumed receptor for IgE on mast cells. III. Kinetics of the blocking of the PCA reaction by cell-free particulate preparations from rat peritoneal mast cells and effect of pH and calcium concentration on the reaction.

Authors: M K Bach; J R Brashler
Journal: Immunology Date: 1976-01 Impact factor: 7.397

10. Histamine release by exocytosis from rat mast cells on reduction of extracellular sodium: a secretory response inhibited by calcium, strontium, barium or magnesium.

Authors: D E Cochrane; W W Douglas
Journal: J Physiol Date: 1976-05 Impact factor: 5.182

The role of the alkaline earth ions in anaphylactic histamine secretion.

1. Improved automatic apparatus for pharmacological assays on isolated preparations.

2. The effect of calcium ions on the motor end-plate potentials.

3. Structural and functional changes of frog neuromuscular junctions in high calcium solutions.

4. Ca++ dependence of histamine release and formation of slow reacting substance in the cat paw.

5. The binding of calcium at lipid-water interfaces.

6. Ultrastructural changes in rat mast cells during anaphylactic histamine release.

7. The mechanism of anaphylactic histamine release from rabbit leucocytes.

8. Some quantitative uses of drug antagonists.

9. A study of the mechanism of quantal transmitter release at a chemical synapse.

10. Strontium and quantal release of transmitter at the neuromuscular junction.

1. Na(+)-dependent Ca(2+) transport modulates the secretory response to the Fcepsilon receptor stimulus of mast cells.

2. On the nature of the presumed receptor for IgE on mast cells. III. Kinetics of the blocking of the PCA reaction by cell-free particulate preparations from rat peritoneal mast cells and effect of pH and calcium concentration on the reaction.

3. Pepsin secretion in the isolated rat stomach preparations [proceedings].

4. Canatoxin triggers histamine secretion from rat peritoneal mast cells.

5. Are gastrin receptors located on parietal cells [proceedings]?

6. Protein and diacylglycerol phosphorylation in the stimulus-secretion coupling of rat mast cells.

7. Characteristics of histamine release from rat mast cells in relation to the valency of the stimulating ligand.

8. Biochemical and functional studies of cortical vesicle fusion: the SNARE complex and Ca2+ sensitivity.

9. Extracellular calcium and cholinergic stimulation of isolated canine parietal cells.

10. Histamine release by exocytosis from rat mast cells on reduction of extracellular sodium: a secretory response inhibited by calcium, strontium, barium or magnesium.