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Literature DB >> 6234011

5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.

C Roobol, G B De Dobbeleer, J L Bernheim.

Abstract

The mode of action of 5-fluorouracil (FUra) and 5-fluoro-2'-deoxyuridine (FdUrd) on L1210 leukaemia has been studied. It is shown that FUra and FdUrd follow different routes of metabolism and have different targets with respect to their cytotoxic activity. FUra is converted to 5-fluorouridine-5'triphosphate ( FUTP ), which is incorporated into nascent RNA. FdUrd is converted to 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP), which inhibits the de novo synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP). Conversion of FUra to FdUMP does occur, but this phenomenon does not contribute to the final cytotoxic effect. No conversion of FdUrd to FUra has been detected.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1984 PMID： 6234011 PMCID： PMC1976839 DOI： 10.1038/bjc.1984.116

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

18 in total

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8. Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.

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5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.

1. Studies on fluorinated pyrimidines. XIII. Inhibition of thymidylate synthetase.

2. THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES.

3. Angiotensin receptors.

4. The synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells.

5. Fluorinated pyrimidines. XL. The reduction of 5-fluorouridine 5'-diphosphate by ribonucleotide reductase.

6. The effect of 5-fluorouridine 5'-triphosphate on RNA transcribed in isolated nuclei in vitro.

7. Rate of DNA synthesis in exponentially growing cell lines in the presence and absence of antimetabolites.

8. Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.

9. 5-Fluoro-2'-deoxyuridine incorporation in L1210 DNA.

10. Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine.

1. Intracellular localization of drugs in cultured tumor cells by ion microscopy and image processing.

2. The role of fluorinated pyrimidine analogues in the induction of the in vitro expression of the fragile X chromosome.

Review 3. Drug repurposing for the treatment of staphylococcal infections.