Literature DB >> 623398

Theophylline bioavailability following oral administration of six sustained-release preparations.

D L Spangler, D D Kalof, F L Bloom, H J Wittig.   

Abstract

Plasma theophylline concentrations were measured in 20 adults after single doses of 8 mg/kg of each of six oral sustained-release theophylline preparations. Twelve subjects were studied in a multiple-dose trial. Comparison of bioavailability and absorption characteristics suggest usefulness of some of these products for the purpose of maintaining safe and effective blood levels with twice-a-day dosing.

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Year:  1978        PMID： 623398

Source DB:  PubMed          Journal:  Ann Allergy        ISSN： 0003-4738


  22 in total

1.  Computer-aided dosage form design. II. Methods for defining a zero-order sustained-release delivery system of maximum formulating flexibility.

Authors:  T Y Lee; R E Notari
Journal:  Pharm Res       Date:  1987-10       Impact factor: 4.200

2.  The effect of age on theophylline clearance in normal subjects.

Authors:  W C Randolph; J J Seaman; B Dickson; K E Peace; W O Frank; M D Young
Journal:  Br J Clin Pharmacol       Date:  1986-11       Impact factor: 4.335

Review 3.  Clinical pharmacokinetics of theophylline.

Authors:  R I Ogilvie
Journal:  Clin Pharmacokinet       Date:  1978 Jul-Aug       Impact factor: 6.447

4.  Food and a sustained release theophylline tablet on chronic dosing: bioavailability, peak-trough and trough-trough differences.

Authors:  M Lagas; J H Jonkman
Journal:  Pharm Weekbl Sci       Date:  1985-02-22

Review 5.  New drugs in respiratory disorders: I.

Authors:  D C Flenley
Journal:  Br Med J (Clin Res Ed)       Date:  1983-03-12

6.  Kinetic interaction between theophylline and a newly developed anti-allergic drug, pemirolast potassium.

Authors:  T Hasegawa; K Takagi; M Nadai; Y Ogura; T Nabeshima
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

7.  Slow release theophyllines and chronic bronchitis.

Authors:  G M Cochrane
Journal:  Br Med J (Clin Res Ed)       Date:  1984-12-15

8.  New method for bioavailability assessment of slow-release preparations of theophylline.

Authors:  Y Kasuya; T Ohno; N Kubota; H Takahashi; H Hirayama
Journal:  J Pharmacokinet Biopharm       Date:  1985-12

9.  Bioavailability and pharmacokinetics of theophylline in plain uncoated and sustained-release dosage forms in relation to smoking habit. I. Single dose study.

Authors:  Y Horai; T Ishizaki; T Sasaki; K Chiba; T Suganuma; H Echizen; A Ohnishi
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

Review 10.  A clinical and pharmacokinetic basis for the selection and use of slow release theophylline products.

Authors:  L Hendeles; R P Iafrate; M Weinberger
Journal:  Clin Pharmacokinet       Date:  1984 Mar-Apr       Impact factor: 6.447
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