Literature DB >> 3834072

New method for bioavailability assessment of slow-release preparations of theophylline.

Y Kasuya, T Ohno, N Kubota, H Takahashi, H Hirayama.   

Abstract

Variability in an individual's clearance of theophylline is an important consideration when estimating bioavailability. A method is described for compensating for this problem, using the serum concentration of theophylline and urinary excretion data on its major metabolites to make an estimation of the clearance after oral administration using the intravenous dose as reference. The method is particularly useful for assessing the bioavailability of slow-release theophylline preparations.

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Year:  1985        PMID： 3834072     DOI： 10.1007/bf01058902

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  17 in total

1.  Relationship of theophylline clearance to oral dosage in children with chronic asthma.

Authors:  E Ginchansky; M Weinberger
Journal:  J Pediatr       Date:  1977-10       Impact factor: 4.406

2.  Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline.

Authors:  J W Jenne; M S Wyze; F S Rood; F M MacDonald
Journal:  Clin Pharmacol Ther       Date:  1972 May-Jun       Impact factor: 6.875

3.  The relation of product formulation to absorption of oral theophylline.

Authors:  M Weinberger; L Hendeles; L Bighley
Journal:  N Engl J Med       Date:  1978-10-19       Impact factor: 91.245

4.  Measurement of excretion characteristics of theophylline and its major metabolites.

Authors:  J H Jonkman; D Tang; R A Upton; S Riegelman
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953

5.  Evaluation of the absorption from 15 commercial theophylline products indicating deficiencies in currently applied bioavailability criteria.

Authors:  R A Upton; L Sansom; T W Guentert; J R Powell; J F Thiercelin; V P Shah; P E Coates; S Riegelman
Journal:  J Pharmacokinet Biopharm       Date:  1980-06

6.  Intraindividual variability in theophylline pharmacokinetics: statistical verification in 39 of 60 healthy young adults.

Authors:  R A Upton; J F Thiercelin; T W Guentert; S M Wallace; J R Powell; L Sansom; S Riegelman
Journal:  J Pharmacokinet Biopharm       Date:  1982-04

7.  Influence of methylxanthine-containing foods on theophylline metabolism and kinetics.

Authors:  T J Monks; J Caldwell; R L Smith
Journal:  Clin Pharmacol Ther       Date:  1979-10       Impact factor: 6.875

8.  Absolute bioavailability of oral theophylline.

Authors:  L Hendeles; M Weinberger; L Bighley
Journal:  Am J Hosp Pharm       Date:  1977-05

9.  Theophylline bioavailability following oral administration of six sustained-release preparations.

Authors:  D L Spangler; D D Kalof; F L Bloom; H J Wittig
Journal:  Ann Allergy       Date:  1978-01

10.  Nonlinear theophylline elimination.

Authors:  D D Tang-Liu; R L Williams; S Riegelman
Journal:  Clin Pharmacol Ther       Date:  1982-03       Impact factor: 6.875
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  1 in total

1.  Evaluation of the utility of a proposed method for correcting for intrasubject variability in metabolic clearance in the bioavailability assessment of theophylline.

Authors:  Y Kasuya; T Furuta; H Shibasaki; H Shimota
Journal:  J Pharmacokinet Biopharm       Date:  1991-02
  1 in total

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