Literature DB >> 6227809

Increased mutational rates in Chinese hamster ovary cells serially selected for drug resistance.

E Drobetsky, M Meuth.   

Abstract

Chinese hamster ovary cell populations exposed to the pressures of prolonged serial cultivation in cytotoxic drugs have increased mutational rates at independent genetic loci. Evidence suggests that the alterations generating these mutations may be independent of the lesions conferring drug resistance.

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Year:  1983        PMID： 6227809      PMCID： PMC370049          DOI： 10.1128/mcb.3.10.1882-1885.1983

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  17 in total

1.  Characterization of a mutator gene in Chinese hamster ovary cells.

Authors:  M Meuth; N L'Heureux-Huard; M Trudel
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

Review 2.  The HPRT locus.

Authors:  C T Caskey; G D Kruh
Journal:  Cell       Date:  1979-01       Impact factor: 41.582

3.  Selection for high mutation rates in chemostats.

Authors:  E C Cox; T C Gibson
Journal:  Genetics       Date:  1974-06       Impact factor: 4.562

4.  Increased frequency of deletions in DNA polymerase mutants of Escherichia coli.

Authors:  M B Coukell; C Yanofsky
Journal:  Nature       Date:  1970-11-14       Impact factor: 49.962

5.  Rapid determination of nucleoside kinase and nucleotidase activities with tritium-labeled substrates.

Authors:  D H Ives; J P Durham; V S Tucker
Journal:  Anal Biochem       Date:  1969-04-04       Impact factor: 3.365

Review 6.  Bacterial mutator genes and the control of spontaneous mutation.

Authors:  E C Cox
Journal:  Annu Rev Genet       Date:  1976       Impact factor: 16.830

7.  Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts.

Authors:  L G Navalgund; C Rossana; A J Muench; L F Johnson
Journal:  J Biol Chem       Date:  1980-08-10       Impact factor: 5.157

8.  Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

Authors:  J H Nunberg; R J Kaufman; R T Schimke; G Urlaub; L A Chasin
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

9.  An isotopic assay for thymidylate synthetase.

Authors:  D Roberts
Journal:  Biochemistry       Date:  1966-11       Impact factor: 3.162

10.  Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

Authors:  R J Kaufman; P C Brown; R T Schimke
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205
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  5 in total

1.  Increased rate of base substitution in a hamster mutator strain obtained during serial selection for gene amplification.

Authors:  M A Caligo; W Armstrong; B J Rossiter; M Meuth
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

2.  Lack of correlation between deoxyribonucleotide pool sizes, spontaneous mutation rates and malignant potential in Chinese hamster ovary cells.

Authors:  A Y Tagger; J E Damen; A H Greenberg; J A Wright
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

3.  Spontaneous rearrangement of integrated simian virus 40 DNA in nine transformed rodent cell lines.

Authors:  T Gurney; E G Gurney
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

Review 4.  Quantitative genetic analysis of tumor progression.

Authors:  V Ling; A F Chambers; J F Harris; R P Hill
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

5.  Mismatch repair deficiency associated with overexpression of the MSH3 gene.

Authors:  G Marra; I Iaccarino; T Lettieri; G Roscilli; P Delmastro; J Jiricny
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-21       Impact factor: 11.205
  5 in total

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