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Literature DB >> 4603159

Selection for high mutation rates in chemostats.

Abstract

Competition experiments in chemostats show that mutator populations of Escherichia coli are more fit than wild type. The increased fitness can be explained by the appearance of new mutants better adapted to the chemostat environment. Fitness values vary between chemostats and are strongly correlated (P < 0.001) with fluctuations in population density.

Entities: Gene Species

Mesh：

Substances：

Year: 1974 PMID： 4603159 PMCID： PMC1213122

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

10 in total

1. Segregation of the Selective Advantage Obtained through Orthoselection in Escherichia Coli.

Authors: D J McDonald
Journal: Genetics Date: 1955-11 Impact factor: 4.562

2. Mutator gene studies in Escherichia coli: the mutS gene.

Authors: E C Cox; G E Degnen; M L Scheppe
Journal: Genetics Date: 1972-12 Impact factor: 4.562

3. Population changes in continuously growing mutator cultures of Escherichia coli.

Authors: E R Nestmann; R F Hill
Journal: Genetics Date: 1973-04 Impact factor: 4.562

4. In vitro characterization of a mutator T4 DNA polymerase.

Authors: M S Hershfield; N G Nossal
Journal: Genetics Date: 1973-04 Impact factor: 4.562

5. Fitness of an Escherichia coli mutator gene.

Authors: T C Gibson; M L Scheppe; E C Cox
Journal: Science Date: 1970-08-14 Impact factor: 47.728

6. Altered base ratios in the DNA of an Escherichia coli mutator strain.

Authors: E C Cox; C Yanofsky
Journal: Proc Natl Acad Sci U S A Date: 1967-11 Impact factor: 11.205

7. The genetics of a mutator gene in Drosophila melanogaster.

Authors: M M Green
Journal: Mutat Res Date: 1970-10 Impact factor: 2.433

8. Genetic analysis of sul mutants of Escherichia coli B.

Authors: J J Donch; Y S Chung; M H Green; J Greenberg; G Warren
Journal: Genet Res Date: 1971-06 Impact factor: 1.588

9. Theory of fitness in a heterogeneous environment. VI. The adaptive significance of mutation.

Authors: R Levins
Journal: Genetics Date: 1967-05 Impact factor: 4.562

10. A proposal for a uniform nomenclature in bacterial genetics.

Authors: M Demerec; E A Adelberg; A J Clark; P E Hartman
Journal: Genetics Date: 1966-07 Impact factor: 4.562

10 in total

42 in total

Selection for high mutation rates in chemostats.

1. Segregation of the Selective Advantage Obtained through Orthoselection in Escherichia Coli.

2. Mutator gene studies in Escherichia coli: the mutS gene.

3. Population changes in continuously growing mutator cultures of Escherichia coli.

4. In vitro characterization of a mutator T4 DNA polymerase.

5. Fitness of an Escherichia coli mutator gene.

6. Altered base ratios in the DNA of an Escherichia coli mutator strain.

7. The genetics of a mutator gene in Drosophila melanogaster.

8. Genetic analysis of sul mutants of Escherichia coli B.

9. Theory of fitness in a heterogeneous environment. VI. The adaptive significance of mutation.

10. A proposal for a uniform nomenclature in bacterial genetics.

Review 1. Mechanisms of stationary phase mutation: a decade of adaptive mutation.

2. Mild environmental stress elicits mutations affecting fitness in Chlamydomonas.

Review 3. Adaptive mutation: implications for evolution.

4. Experimental analysis of molecular events during mutational periodic selections in bacterial evolution.

5. The role of transient hypermutators in adaptive mutation in Escherichia coli.

6. Mutator genes and selection for the mutation rate in bacteria.

7. The evolution of mutator genes in bacterial populations: the roles of environmental change and timing.

Review 8. New insights into bacterial adaptation through in vivo and in silico experimental evolution.

9. Direct selection for mutators in Escherichia coli.

10. The speed of evolution and maintenance of variation in asexual populations.