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Literature DB >> 6226282

Fructose 2,6-bisphosphate in livers of genetically obese rats.

Abstract

Livers of genetically obese (fa/fa) rats, starved for 24 h, contained more fructose 2,6-bisphosphate, glucose 6-phosphate, fructose 6-phosphate and glycogen, and more pyruvate kinase and phosphofructokinase 2 activities, than livers of control lean rats. These changes may be explained in terms of cyclic AMP concentration, which was decreased in livers of obese starved rats.

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Year: 1983 PMID： 6226282 PMCID： PMC1152349 DOI： 10.1042/bj2141019

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. Regulation in vitro and in vivo of adenosine 3':5'-monophosphate-dependent inactivation of rat-liver pyruvate kinase type L.

Authors: J E Felíu; L Hue; H G Hers
Journal: Eur J Biochem Date: 1977-12

2. A simplified procedure for the assay of adenosine 3':5'-monophosphate by the activation of liver phosphorylase.

Authors: G Van de Werve; G Van den Berghe; H G Hers
Journal: Eur J Biochem Date: 1974-01-03

3. Coated charcoal immunoassay of insulin.

Authors: V Herbert; K S Lau; C W Gottlieb; S J Bleicher
Journal: J Clin Endocrinol Metab Date: 1965-10 Impact factor: 5.958

4. The effects of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations.

Authors: L Hue; F Bontemps; H Hers
Journal: Biochem J Date: 1975-10 Impact factor: 3.857

5. Hormone-induced changes in pyruvate kinase. Effects of glucagon and starvation.

Authors: T J van Berkel; J K Kruijt; J F Koster
Journal: Eur J Biochem Date: 1977-12

6. The effect of fasting on tissue cyclic cAMP and plasma glucagon in the obese hyperglycemic mouse.

Authors: R L Lavine; N Voyles; P V Perrino; L Recant
Journal: Endocrinology Date: 1975-09 Impact factor: 4.736

7. Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes.

Authors: J E Feliú; L Hue; H G Hers
Journal: Proc Natl Acad Sci U S A Date: 1976-08 Impact factor: 11.205

8. Adaptive responses of enzymes of carbohydrate and lipid metabolism to dietary alteration in genetically obese Zucker rats (fa/fa).

Authors: S O Spydevold; A L Greenbaum; N Z Baquer; P McLean
Journal: Eur J Biochem Date: 1978-09-01

Fructose 2,6-bisphosphate in livers of genetically obese rats.

1. Regulation in vitro and in vivo of adenosine 3':5'-monophosphate-dependent inactivation of rat-liver pyruvate kinase type L.

2. A simplified procedure for the assay of adenosine 3':5'-monophosphate by the activation of liver phosphorylase.

3. Coated charcoal immunoassay of insulin.

4. The effects of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations.

5. Hormone-induced changes in pyruvate kinase. Effects of glucagon and starvation.

6. The effect of fasting on tissue cyclic cAMP and plasma glucagon in the obese hyperglycemic mouse.

7. Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes.

8. Adaptive responses of enzymes of carbohydrate and lipid metabolism to dietary alteration in genetically obese Zucker rats (fa/fa).

9. A protein binding assay for adenosine 3':5'-cyclic monophosphate.

10. Modulation of the phosphorylation state of rat liver pyruvate kinase by allosteric effectors and insulin.

1. The onset of liver glycogen synthesis in fasted-refed lean and genetically obese (fa/fa) rats.

Review 2. Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues.

Review 3. An hypothesis on the aetiology of obesity: dysfunction of the central nervous system as a primary cause.

4. Contribution of glycerol and alanine to basal hepatic glucose production in the genetically obese (fa/fa) rat.

5. Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats.