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Literature DB >> 6213152

Expression of the marker (X) (q28) in lymphoblastoid cell lines.

P A Jacobs, P A Hunt, M Mayer, J C Wang, G R Boss, R W Erbe.

Abstract

The marker(X)(q28) chromosome associated with one type of X-linked mental retardation has been demonstrated in lymphoblastoid cell lines established from affected individuals. The mar(x) can reliably and repeatedly be seen by the addition of FUdR to the cultures for 24 hrs prior to harvest. This simple technique provides an excellent in vitro experimental test system for investigation of the mar(X).

Entities: Disease

Mesh：

Substances：

Year: 1982 PMID： 6213152 PMCID： PMC1685369

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

9 in total

1. Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.

Authors: G R Sutherland
Journal: Science Date: 1977-07-15 Impact factor: 47.728

2. Marker X chromosome induction in fibroblasts by FUdR.

Authors: N Tommerup; K B Nielssen; M Mikkelsen
Journal: Am J Med Genet Date: 1981

3. X-linked mental retardation: a study of 7 families.

Authors: P A Jacobs; T W Glover; M Mayer; P Fox; J W Gerrard; H G Dunn; D S Herbst
Journal: Am J Med Genet Date: 1980

4. X-linked mental retardation, macro-orchidism, and the Xq27 fragile site.

Authors: G Turner; A Daniel; M Frost
Journal: J Pediatr Date: 1980-05 Impact factor: 4.406

5. Release of infectious Epstein-Barr virus by transformed marmoset leukocytes.

Authors: G Miller; M Lipman
Journal: Proc Natl Acad Sci U S A Date: 1973-01 Impact factor: 11.205

6. Permanent lymphoid lines from genetically marked lymphocytes: success with lymphocytes recovered from frozen storage.

Authors: W S Sly; G S Sekhon; R Kennett; W F Bodmer; J Bodmer
Journal: Tissue Antigens Date: 1976-03

7. Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein-Barr virus-induced B-cell lines.

Authors: A G Bird; S M McLachlan; S Britton
Journal: Nature Date: 1981-01-22 Impact factor: 49.962

8. Familial X-linked mental retardation with an X chromosome abnormality.

Authors: J Harvey; C Judge; S Wiener
Journal: J Med Genet Date: 1977-02 Impact factor: 6.318

9. FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

Authors: T W Glover
Journal: Am J Hum Genet Date: 1981-03 Impact factor: 11.025

9 in total

19 in total

8. Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression.

Authors: K B Nielsen; N Tommerup
Journal: Hum Genet Date: 1984 Impact factor: 4.132

9. A fragile X suppressor in the normal human blood?

Authors: D Soudek; M Emanuel
Journal: Hum Genet Date: 1983 Impact factor: 4.132

10. Fragile (X) expression: relationship to the cell cycle.

Authors: E S Cantú; P A Jacobs
Journal: Hum Genet Date: 1984 Impact factor: 4.132

Expression of the marker (X) (q28) in lymphoblastoid cell lines.

1. Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.

2. Marker X chromosome induction in fibroblasts by FUdR.

3. X-linked mental retardation: a study of 7 families.

4. X-linked mental retardation, macro-orchidism, and the Xq27 fragile site.

5. Release of infectious Epstein-Barr virus by transformed marmoset leukocytes.

6. Permanent lymphoid lines from genetically marked lymphocytes: success with lymphocytes recovered from frozen storage.

7. Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein-Barr virus-induced B-cell lines.

8. Familial X-linked mental retardation with an X chromosome abnormality.

9. FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

1. Induction of distamycin A-inducible rare fragile sites and increased sister chromatid exchanges at the fragile site.

2. The effect of methionine and 5-azacytidine on fragile X expression.

3. DNA demethylation induced by 5-azacytidine does not affect fragile X expression.

4. Studies on three rare fragile sites. 2q13, 12q13, and 17p12 segregating in one family.

5. A comparison of fragile X expression in lymphocyte and lymphoblastoid cultures.

6. Linkage and recombination between fragile X-linked mental retardation and the factor IX gene.

7. The effect of Y-chromosome alpha-satellite array length on the rate of sex chromosome disomy in human sperm.

8. Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression.

9. A fragile X suppressor in the normal human blood?

10. Fragile (X) expression: relationship to the cell cycle.