Literature DB >> 6207974

Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans.

T O Rosenbach, S Moshonov, U Zor, M Yaron.   

Abstract

From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblasts in vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.

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Year:  1984        PMID： 6207974     DOI： 10.1007/bf02032343

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  26 in total

1.  Virus antibody in synovial fluid of rheumatoid and control patients.

Authors:  F Stanford
Journal:  Ann Rheum Dis       Date:  1974-07       Impact factor: 19.103

Review 2.  Interferons and interferon inducers: development of clinical usefulness and therapeutic promise.

Authors:  R B Pollard
Journal:  Drugs       Date:  1982 Jan-Feb       Impact factor: 9.546

3.  The probable role of interferon in allergy.

Authors:  S V Skurkovich; E I Eremkina
Journal:  Ann Allergy       Date:  1975-12

4.  Isolation of rubella virus from synovial fluid in five cases of seronegative arthritis.

Authors:  R Grahame; R Armstrong; N A Simmons; C A Mims; J M Wilton; R Laurent
Journal:  Lancet       Date:  1981-09-26       Impact factor: 79.321

5.  The role of prostaglandins in experimental arthritis in the rat.

Authors:  Y Floman; E Okon; U Zor
Journal:  Clin Orthop Relat Res       Date:  1977-06       Impact factor: 4.176

6.  Hyaluronic acid produced by human synovial fibroblasts. Effect of polyinosinic-polycytidylic acid (poly I:C) and interferon.

Authors:  M Yaron; I Yaron; O Smetana; E Eylan; M Herzberg
Journal:  Arthritis Rheum       Date:  1976 Nov-Dec

7.  Interferon in synovial fluid and serum of patients with rheumatic disease.

Authors:  T C Cesario; B S Andrews; D A Martin; M Jason; T Treadwell; G Friou; J G Tilles
Journal:  J Rheumatol       Date:  1983-08       Impact factor: 4.666

8.  Stimulation of prostaglandin E production by bacterial endotoxins in cultured human synovial fibroblasts.

Authors:  M Yaron; I Yaron; O Smetana; E Eylan; U Zor
Journal:  Arthritis Rheum       Date:  1980-08

9.  Natural killer cell activity of mononuclear cells from rheumatoid patients measured by a conjugate-binding cytotoxicity assay.

Authors:  E Reinitz; P A Neighbour; A I Grayzel
Journal:  Arthritis Rheum       Date:  1982-12

10.  Acute induction of joint inflammation in the rat by poly I . poly C.

Authors:  M Yaron; M Baratz; I Yaron; U Zor
Journal:  Inflammation       Date:  1979-07       Impact factor: 4.092
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