Literature DB >> 195764

The role of prostaglandins in experimental arthritis in the rat.

Y Floman, E Okon, U Zor.   

Abstract

In the experimental model of streptococcal CFE-induced arthritis, PGE and PGF concentrations rise significantly. This is due to an increase both in the substrate concentration and the enzyme activity for PG biosynthesis. Indomethacin therapy inhibited PG synthesis and diminished some of the gross, but not the histological, features of the inflammatory response. These results lend further support to the contention that the beneficial effect of indomethacin in arthritis is due to inhibition of PG biosynthesis.

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Year:  1977        PMID： 195764

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN： 0009-921X            Impact factor:   4.176


  6 in total

1.  Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats.

Authors:  N Turull; J Queralt
Journal:  Inflammation       Date:  2000-12       Impact factor: 4.092

2.  No effects of piroxicam on osteopenia and recovery after Colles' fracture. A randomized, double-blind, placebo-controlled, prospective trial.

Authors:  P Adolphson; H Abbaszadegan; U Jonsson; N Dalén; H E Sjöberg; S Kalén
Journal:  Arch Orthop Trauma Surg       Date:  1993       Impact factor: 3.067

3.  Acute induction of joint inflammation in the rat by poly I . poly C.

Authors:  M Yaron; M Baratz; I Yaron; U Zor
Journal:  Inflammation       Date:  1979-07       Impact factor: 4.092

4.  A pharmacological analysis of the responses of isolated aorta from rats with adjuvant arthritis.

Authors:  J Fontaine; A Herchuelz; J P Famaey
Journal:  Agents Actions       Date:  1984-06

Review 5.  Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans.

Authors:  T O Rosenbach; S Moshonov; U Zor; M Yaron
Journal:  Clin Rheumatol       Date:  1984-09       Impact factor: 2.980

Review 6.  Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine.

Authors:  Seidu A Richard; Sylvanus Kampo; Maite Esquijarosa Hechavarria; Marian Sackey; Alexis D B Buunaaim; Eugene Dogkotenge Kuugbee; Thomas Winsum Anabah
Journal:  J Immunol Res       Date:  2020-09-25       Impact factor: 4.818
  6 in total

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