Literature DB >> 6157394

Stimulation of prostaglandin E production by bacterial endotoxins in cultured human synovial fibroblasts.

M Yaron, I Yaron, O Smetana, E Eylan, U Zor.   

Abstract

E coli, shigella, salmonella, and cholera endotoxins stimulated prostaglandin E (PGE) production by cultured human synovial and foreskin fibroblasts. The minimal effective dose of Shigella endotoxin was 2 micrograms/ml and a maximal response was observed at 10 micrograms/ml. PGE stimulation was first detected 7 hours after addition of cholera endotoxin. Stimulation by shigella endotoxin of both PGE and hyaluronic acid production was inhibited by indomethacin and aspirin. The present results suggest that PGE is a mediator of joint inflammation induced by endotoxins.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6157394     DOI： 10.1002/art.1780230807

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  7 in total

1.  Activation of glomerular mesangial cells by gram-negative bacterial cell wall components.

Authors:  D H Lovett; S L Bursten; D Gemsa; W Bessler; K Resch; J L Ryan
Journal:  Am J Pathol       Date:  1988-12       Impact factor: 4.307

2.  Inhibition of polymorphonuclear leucocyte functions in vivo by Yersinia enterocolitica lipopolysaccharide.

Authors:  K T Hartiala; I Granberg; A Toivanen; M Viljanen
Journal:  Ann Rheum Dis       Date:  1989-01       Impact factor: 19.103

3.  Impact of salmonella infection on host hormone metabolism revealed by metabolomics.

Authors:  L Caetano M Antunes; Ellen T Arena; Alfredo Menendez; Jun Han; Rosana B R Ferreira; Michelle M C Buckner; Petra Lolic; Lufiani L Madilao; Jörg Bohlmann; Christoph H Borchers; B Brett Finlay
Journal:  Infect Immun       Date:  2011-02-14       Impact factor: 3.441

4.  Absence of lipopolysaccharide in the Lyme disease spirochete, Borrelia burgdorferi.

Authors:  K Takayama; R J Rothenberg; A G Barbour
Journal:  Infect Immun       Date:  1987-09       Impact factor: 3.441

5.  Roles of Ca2+ and protein kinase C in regulation of prostaglandin E2 release by cultured rabbit gastric epithelial cells.

Authors:  S Ota; Y Hata; A Terano; K Yoshiura; H Hiraishi; T Kawabe; H Mutoh; S Shiina; T Sugimoto
Journal:  Dig Dis Sci       Date:  1993-08       Impact factor: 3.199

6.  Bacterial lipopolysaccharides induce in vitro degradation of cartilage matrix through chondrocyte activation.

Authors:  H E Jasin
Journal:  J Clin Invest       Date:  1983-12       Impact factor: 14.808

Review 7.  Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans.

Authors:  T O Rosenbach; S Moshonov; U Zor; M Yaron
Journal:  Clin Rheumatol       Date:  1984-09       Impact factor: 2.980
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.