Literature DB >> 6193792

Human alpha-fetoprotein-fatty acid interaction.

C Aussel, R Masseyeff.   

Abstract

Human alpha-fetoprotein (AFP) is able to bind arachidonic acid with high affinity Ka = 10(7)M-1 and a limited number of binding sites NS = 3. Thirty different fatty acids were tested by competition using labelled arachidonic acid as tracer. This experiment demonstrated a great specificity for the fatty acid-AFP interaction. Only polyunsaturated long chain fatty acids were able to bind to AFP with high affinity. The metabolic products of arachidonic acid i.e. prostaglandins presented no affinity for the AFP molecule.

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Year:  1983        PMID： 6193792     DOI： 10.1016/0006-291x(83)90965-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  Drug-binding properties of rat alpha-foetoprotein. Specificities of the phenylbutazone-binding and warfarin-binding sites.

Authors:  F Hervé; K M Rajkowski; M T Martin; P Dessen; N Cittanova
Journal:  Biochem J       Date:  1986-10-15       Impact factor: 3.857

2.  Daunomycin-arachidonic acid complex as a potential new antitumor agent.

Authors:  T Sasaki; Y Tsukada; H F Deutsch; H Hirai
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

3.  Elucidating Binding Sites and Affinities of ERα Agonists and Antagonists to Human Alpha-Fetoprotein by In Silico Modeling and Point Mutagenesis.

Authors:  Nurbubu T Moldogazieva; Daria S Ostroverkhova; Nikolai N Kuzmich; Vladimir V Kadochnikov; Alexander A Terentiev; Yuri B Porozov
Journal:  Int J Mol Sci       Date:  2020-01-30       Impact factor: 5.923
  3 in total

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