Literature DB >> 6198324

Degradation of rRNA in interferon-treated vaccinia virus-infected cells.

B B Goswami, O K Sharma.   

Abstract

In interferon-treated mouse L cells, following infection with a DNA-containing virus, vaccinia, synthesis of unique 2'-5'-linked oligonucleotides of the general formula ppp5'A2'(p5'A)n, abbreviated as 2-5A, was detected by competition radiobinding assay. In addition, degradation of rRNA into discrete and characteristic products, similar to those produced by 2-5A-activated endonuclease, was observed. The degradation of rRNA may represent a significant component of antiviral action of interferon in vaccinia virus-infected cells.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6198324

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  8 in total

1.  Structure and expression of the vaccinia virus gene which prevents virus-induced breakdown of RNA.

Authors:  R F Pacha; R J Meis; R C Condit
Journal:  J Virol       Date:  1990-08       Impact factor: 5.103

2.  La Crosse virus infection of mammalian cells induces mRNA instability.

Authors:  R Raju; D Kolakofsky
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

3.  Modulation of ppp(A2'p)nA-dependent RNase by a temperature-sensitive mutant of vaccinia virus.

Authors:  R J Cohrs; R C Condit; R F Pacha; C L Thompson; O K Sharma
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

4.  Characterization of a temperature-sensitive mutant of vaccinia virus reveals a novel function that prevents virus-induced breakdown of RNA.

Authors:  R F Pacha; R C Condit
Journal:  J Virol       Date:  1985-11       Impact factor: 5.103

5.  Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells.

Authors:  N M Cirino; G Li; W Xiao; P F Torrence; R H Silverman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

6.  Novel 2',5'-oligoadenylates synthesized in interferon-treated, vaccinia virus-infected cells.

Authors:  A P Rice; S M Kerr; W K Roberts; R E Brown; I M Kerr
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

7.  Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication.

Authors:  D Watling; H T Serafinowska; C B Reese; I M Kerr
Journal:  EMBO J       Date:  1985-02       Impact factor: 11.598

Review 8.  The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.

Authors:  M R Player; P F Torrence
Journal:  Pharmacol Ther       Date:  1998-05       Impact factor: 12.310
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.