Literature DB >> 2410258

Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication.

D Watling, H T Serafinowska, C B Reese, I M Kerr.   

Abstract

Chemically synthesised CH3Sp(A2'p)2A2'pp3'OCH3 has been used to assess the importance of the ppp(A2'p)nA (n greater than or equal to 2: 2-5A) system in the antiviral action of interferon against encephalomyocarditis virus (EMC). It inhibits activation of the 2-5A-dependent RNase by 2-5A in intact mouse L929 cells and cell-free systems. In interferon-treated, EMC-infected L929 cells it inhibits 2-5A-mediated rRNA cleavage and partially restores EMC RNA synthesis and virus yield. Activation of the 2-5A-dependent RNase must, therefore, play some part in interferon action against the growth of EMC virus in such cells.

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Year:  1985        PMID： 2410258      PMCID： PMC554204          DOI： 10.1002/j.1460-2075.1985.tb03647.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  25 in total

1.  Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.

Authors:  A G Hovanessian; J Wood; E Meurs; L Montagnier
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

2.  Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells.

Authors:  B R Williams; R R Golgher; R E Brown; C S Gilbert; I M Kerr
Journal:  Nature       Date:  1979-12-06       Impact factor: 49.962

3.  pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

Authors:  I M Kerr; R E Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

4.  Enzymic synthesis, characterisation and nuclear-magnetic-resonance spectra of pppA2'p5'A2'p5'A and related oligonucleotides: comparison with chemically synthesised material.

Authors:  E M Martin; N J Birdsall; R E Brown; I M Kerr
Journal:  Eur J Biochem       Date:  1979-04-02

5.  2-5A synthetase: assay, distribution and variation with growth or hormone status.

Authors:  G R Stark; W J Dower; R T Schimke; R E Brown; I M Kerr
Journal:  Nature       Date:  1979-03-29       Impact factor: 49.962

6.  Radioimmune, radiobinding and HPLC analysis of 2-5A and related oligonucleotides from intact cells.

Authors:  M Knight; P J Cayley; R H Silverman; D H Wreschner; C S Gilbert; R E Brown; I M Kerr
Journal:  Nature       Date:  1980-11-13       Impact factor: 49.962

7.  Anticellular and antiviral effects of pppA(2'p5'A)n.

Authors:  A G Hovanessian; J N Wood
Journal:  Virology       Date:  1980-02       Impact factor: 3.616

8.  Analogs of (2'-5')oligo(A). Endonuclease activation and inhibition of protein synthesis in intact cells.

Authors:  C Baglioni; S B D'Alessandro; T W Nilsen; J A den Hartog; R Crea; J H van Boom
Journal:  J Biol Chem       Date:  1981-04-10       Impact factor: 5.157

9.  A mouse cell line, which is unprotected by interferon against lytic virus infection, lacks ribonuclease F activity.

Authors:  D A Epstein; C W Czarniecki; H Jacobsen; R M Friedman; A Panet
Journal:  Eur J Biochem       Date:  1981-08

10.  Ribosomal RNA cleavage, nuclease activation and 2-5A(ppp(A2'p)nA) in interferon-treated cells.

Authors:  D H Wreschner; T C James; R H Silverman; I M Kerr
Journal:  Nucleic Acids Res       Date:  1981-04-10       Impact factor: 16.971
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  9 in total

1.  Modulation of ppp(A2'p)nA-dependent RNase by a temperature-sensitive mutant of vaccinia virus.

Authors:  R J Cohrs; R C Condit; R F Pacha; C L Thompson; O K Sharma
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

Review 2.  Diverse functions of RNase L and implications in pathology.

Authors:  Catherine Bisbal; Robert H Silverman
Journal:  Biochimie       Date:  2007-02-20       Impact factor: 4.079

3.  Studies on the role of the 2'-5'-oligoadenylate synthetase-RNase L pathway in beta interferon-mediated inhibition of encephalomyocarditis virus replication.

Authors:  R Kumar; D Choubey; P Lengyel; G C Sen
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

4.  Interferon action: binding of viral RNA to the 40-kilodalton 2'-5'-oligoadenylate synthetase in interferon-treated HeLa cells infected with encephalomyocarditis virus.

Authors:  G Gribaudo; D Lembo; G Cavallo; S Landolfo; P Lengyel
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

5.  RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.

Authors:  X L Li; J A Blackford; B A Hassel
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

6.  RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells.

Authors:  C Martinand; C Montavon; T Salehzada; M Silhol; B Lebleu; C Bisbal
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

7.  Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.

Authors:  P Benech; Y Mory; M Revel; J Chebath
Journal:  EMBO J       Date:  1985-09       Impact factor: 11.598

8.  A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.

Authors:  B A Hassel; A Zhou; C Sotomayor; A Maran; R H Silverman
Journal:  EMBO J       Date:  1993-08       Impact factor: 11.598

Review 9.  The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.

Authors:  M R Player; P F Torrence
Journal:  Pharmacol Ther       Date:  1998-05       Impact factor: 12.310
  9 in total

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