Literature DB >> 6179928

cdc9 ligase-defective mutants of Saccharomyces cerevisiae exhibit lowered resistance to lethal effects of bleomycin.

C W Moore.   

Abstract

Conditional ligase-deficient mutants of Saccharomyces cerevisiae were more sensitive than their parental (CDC9) strain to dose-dependent killing by bleomycin, even when mutant cells were pregrown and exposed to the antibiotic at permissive temperatures. Pretreatment incubation at the restrictive temperature (37 degrees C) under growing or nongrowing conditions enhanced bleomycin killing of both cdc9-1 and cdc9-9 mutants. This sensitization could be relieved by incubation at the permissive temperature before treatment.

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Year:  1982        PMID： 6179928      PMCID： PMC220448          DOI： 10.1128/jb.151.3.1617-1620.1982

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  19 in total

1.  Genetic control of the cell division cycle in yeast. 3. Seven genes controlling nuclear division.

Authors:  J Culotti; L H Hartwell
Journal:  Exp Cell Res       Date:  1971-08       Impact factor: 3.905

2.  Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.

Authors:  L H Hartwell; R K Mortimer; J Culotti; M Culotti
Journal:  Genetics       Date:  1973-06       Impact factor: 4.562

3.  Noncovalent intermolecular crosslinks are produced by bleomycin reaction with duplex DNA.

Authors:  R S Lloyd; C W Haidle; D L Robberson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

4.  Sequential function of gene products relative to DNA synthesis in the yeast cell cycle.

Authors:  L H Hartwell
Journal:  J Mol Biol       Date:  1976-07-15       Impact factor: 5.469

5.  Ligase-deficient yeast cells exhibit defective DNA rejoining and enhanced gamma ray sensitivity.

Authors:  C W Moore
Journal:  J Bacteriol       Date:  1982-06       Impact factor: 3.490

6.  The involvement of polynucleotide ligase in the repair of UV-induced DNA damage in Escherichia coli K-12 cells.

Authors:  D A Youngs; K C Smith
Journal:  Mol Gen Genet       Date:  1977-03-28

7.  Modulation of bleomycin cytotoxicity.

Authors:  C W Moore
Journal:  Antimicrob Agents Chemother       Date:  1982-04       Impact factor: 5.191

Review 8.  Genetic toxicology of bleomycin.

Authors:  B K Vig; R Lewis
Journal:  Mutat Res       Date:  1978       Impact factor: 2.433

9.  Macromolecule synthesis in temperature-sensitive mutants of yeast.

Authors:  L H Hartwell
Journal:  J Bacteriol       Date:  1967-05       Impact factor: 3.490

10.  DNA ligase mutants of Escherichia coli.

Authors:  M Gellert; M L Bullock
Journal:  Proc Natl Acad Sci U S A       Date:  1970-11       Impact factor: 11.205
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  4 in total

1.  Growth phase dependency of chromatin cleavage and degradation by bleomycin.

Authors:  C W Moore; C S Jones; L A Wall
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

2.  Further characterizations of bleomycin-sensitive (blm) mutants of Saccharomyces cerevisiae with implications for a radiomimetic model.

Authors:  C W Moore
Journal:  J Bacteriol       Date:  1991-06       Impact factor: 3.490

3.  Functional analysis of subcellular localization and protein-protein interaction sequences in the essential DNA ligase I protein of fission yeast.

Authors:  Ina V Martin; Stuart A MacNeill
Journal:  Nucleic Acids Res       Date:  2004-01-29       Impact factor: 16.971

4.  Potentiation of bleomycin cytotoxicity in Saccharomyces cerevisiae.

Authors:  C W Moore
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191
  4 in total

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