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Literature DB >> 325385

The involvement of polynucleotide ligase in the repair of UV-induced DNA damage in Escherichia coli K-12 cells.

Abstract

The effect of the ligts-7 mutation on cell survival and the extent of DNA repair after UV (254 nm) irradiation was determined for wild-type and uvrB5 cells of E. coli K-12 at 30 degrees and 42 degrees C. At the restrictive temperature (42 degrees C) the ligts-7 mutation resulted in (i) a decrease in the extent of repair of DNA incision breaks arising during the excision repair process, and (ii) a decrease in the extent of post-replicational repair of gaps in newly-synthesized DNA. These deficiencies in DNA repair correlated with increases in cellular sensitivity to killing by UV radiation. Thus, DNA lagase plays an important role in vivo in both the excision and post-replicational repair processes.

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Year: 1977 PMID： 325385 DOI： 10.1007/bf00264937

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

25 in total

Review 1. Enzymatic repair of DNA.

Authors: L Grossman; A Braun; R Feldberg; I Mahler
Journal: Annu Rev Biochem Date: 1975 Impact factor: 23.643

2. THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM.

Authors: R B SETLOW; W L CARRIER
Journal: Proc Natl Acad Sci U S A Date: 1964-02 Impact factor: 11.205

3. Role for deoxyribonucleic acid ligase in deoxyribonucleic acid polymerase i-dependent repair synthesis in toluene-treated escherichia coli.

Authors: D Billen; G R Hellermann; D R Stallions
Journal: J Bacteriol Date: 1975-10 Impact factor: 3.490

4. Sensitization of ultraviolet-irradiated Escherichia coli K-12 by different agars: inhibition of A rec and exr gene-dependent branch of the uvr gene-dependent excision-repair process.

Authors: E Van der Schueren; D A Youngs; K C Smith
Journal: Photochem Photobiol Date: 1974-07 Impact factor: 3.421

5. Isolation and characterization of thermosensitive Escherichia coli mutants defective in deoxyribonucleic acid replication.

Authors: J A Wechsler; V Nüsslein; B Otto; A Klein; F Bonhoeffer; R Herrmann; L Gloger; H Schaller
Journal: J Bacteriol Date: 1973-03 Impact factor: 3.490

6. Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase.

Authors: E B Konrad; P Modrich; I R Lehman
Journal: J Mol Biol Date: 1973-07-15 Impact factor: 5.469

1. Involvement of helicase II (uvrD gene product) and DNA polymerase I in excision mediated by the uvrABC protein complex.

Authors: P R Caron; S R Kushner; L Grossman
Journal: Proc Natl Acad Sci U S A Date: 1985-08 Impact factor: 11.205

The involvement of polynucleotide ligase in the repair of UV-induced DNA damage in Escherichia coli K-12 cells.

Review 1. Enzymatic repair of DNA.

2. THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM.

3. Role for deoxyribonucleic acid ligase in deoxyribonucleic acid polymerase i-dependent repair synthesis in toluene-treated escherichia coli.

4. Sensitization of ultraviolet-irradiated Escherichia coli K-12 by different agars: inhibition of A rec and exr gene-dependent branch of the uvr gene-dependent excision-repair process.

5. Isolation and characterization of thermosensitive Escherichia coli mutants defective in deoxyribonucleic acid replication.

6. Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase.

7. In vitro repair of single-strand breaks in -irradiated DNA by polynucleotide ligase.

8. Semi-in vitro repair of radiation-induced damage in transforming DNA of Bacillus subtilis.

9. Excision of pyrimidine dimers in toluene-treated Escherichia coli.

10. Excision repair of ultraviolet-irradiated deoxyribonucleic acid in plasmolyzed cells of Escherichia coli.

1. Involvement of helicase II (uvrD gene product) and DNA polymerase I in excision mediated by the uvrABC protein complex.

2. Defective excision and postreplication repair of UV-damaged DNA in a recL mutant strain of E. coli K-12.

Review 3. Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda.

4. A DNA excision repair system for Neisseria gonorrhoeae.

5. The genetics and specificity of the constitutive excision repair system of Bacillus subtilis.

6. cdc9 ligase-defective mutants of Saccharomyces cerevisiae exhibit lowered resistance to lethal effects of bleomycin.