Literature DB >> 6178735

Stoichiometry of DNA strand scission and aldehyde formation by bleomycin.

R M Burger, J Peisach, S B Horwitz.   

Abstract

A colorimetric assay of DNA breakage by bleomycin has been standardized and indicates that strand scission is stoichiometric with the formation of a single equivalent of an aldehyde compound consisting of base plus deoxyribose carbons 1' to 3'. Both strand scission and aldehyde formation require the presence of O2. An alternate DNA lesion inflicted by bleomycin, alkali labilization, is O2-dependent, as is the accompanying release of free bases.

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Year:  1982        PMID： 6178735

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  Filamin-A as a marker and target for DNA damage based cancer therapy.

Authors:  Jingyin Yue; Huimei Lu; Jingmei Liu; Marianne Berwick; Zhiyuan Shen
Journal:  DNA Repair (Amst)       Date:  2011-11-02

Review 2.  Mechanism of DNA-drug interactions.

Authors:  P Prabhakar; A M Kayastha
Journal:  Appl Biochem Biotechnol       Date:  1994-04       Impact factor: 2.926

3.  Identification of oligonucleotide fragments produced in a strand scission reaction of the d(C-G-C-G-C-G) duplex by bleomycin.

Authors:  S Uesugi; T Shida; M Ikehara; Y Kobayashi; Y Kyogoku
Journal:  Nucleic Acids Res       Date:  1984-02-10       Impact factor: 16.971

Review 4.  Mechanisms of bleomycin-induced lung damage.

Authors:  J Hay; S Shahzeidi; G Laurent
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

5.  Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA.

Authors:  Trevor C Bozeman; Rupesh Nanjunda; Chenhong Tang; Yang Liu; Zachary J Segerman; Paul A Zaleski; W David Wilson; Sidney M Hecht
Journal:  J Am Chem Soc       Date:  2012-10-22       Impact factor: 15.419

6.  Malondialdehyde precursors in gamma-irradiated DNA, deoxynucleotides and deoxynucleosides.

Authors:  M F Janicek; W A Haseltine; W D Henner
Journal:  Nucleic Acids Res       Date:  1985-12-20       Impact factor: 16.971

Review 7.  Protective mechanisms against the antitumor agent bleomycin: lessons from Saccharomyces cerevisiae.

Authors:  Dindial Ramotar; Huijie Wang
Journal:  Curr Genet       Date:  2003-04-16       Impact factor: 3.886

8.  Diethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin.

Authors:  K R Fox; G W Grigg
Journal:  Nucleic Acids Res       Date:  1988-03-25       Impact factor: 16.971

9.  DNA cleavage and detection of DNA radicals formed from hydralazine and copper (II) by ESR and immuno-spin trapping.

Authors:  Birandra K Sinha; Fabian Leinisch; Suchandra Bhattacharjee; Ronald P Mason
Journal:  Chem Res Toxicol       Date:  2014-02-13       Impact factor: 3.739

10.  ESR of copper and iron complexes with antitumor and cytotoxic properties.

Authors:  W E Antholine; B Kalyanaraman; D H Petering
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031
  10 in total

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