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Literature DB >> 2451809

Diethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin.

Abstract

DNA structural changes induced by bleomycin have been investigated using diethylpyrocarbonate and permanganate as probes under conditions in which the antibiotic binds to, but does not cut the DNA. Diethyl-pyrocarbonate shows an enhanced reaction with adenines in the presence of the antibiotic in the sequences GTA greater than GCA greater than GAA, on the 3' side of the drug cutting site (GPy). Permanganate ions display an enhanced reactivity at the second pyrimidine of the sequence GPyPy. The results are consistent with a model in which bleomycin distorts the structure of the base pair on the 3' side of its binding site.

Entities: Chemical Gene

Mesh：

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Year: 1988 PMID： 2451809 PMCID： PMC338199 DOI： 10.1093/nar/16.5.2063

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

26 in total

1. The selective degradation of pyrimidines in nucleic acids by permanganate oxidation.

Authors: H Hayatsu; T Ukita
Journal: Biochem Biophys Res Commun Date: 1967-11-30 Impact factor: 3.575

2. Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

Authors: A D D'Andrea; W A Haseltine
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

3. A role for ferrous ion and oxygen in the degradation of DNA by bleomycin.

Authors: E A Sausville; J Peisach; S B Horwitz
Journal: Biochem Biophys Res Commun Date: 1976-12-06 Impact factor: 3.575

4. Pyrimidine-specific chemical reactions useful for DNA sequencing.

Authors: C M Rubin; C W Schmid
Journal: Nucleic Acids Res Date: 1980-10-24 Impact factor: 16.971

5. Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding.

Authors: L F Povirk; M Hogan; N Dattagupta; M Buechner
Journal: Biochemistry Date: 1981-02-03 Impact factor: 3.162

6. Effects of O2 on the reactions of activated bleomycin.

Authors: R M Burger; J Peisach; S B Horwitz
Journal: J Biol Chem Date: 1982-04-10 Impact factor: 5.157

7. Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.

Authors: R M Burger; J Peisach; S B Horwitz
Journal: J Biol Chem Date: 1981-11-25 Impact factor: 5.157

8. Characterization of two xenopus somatic 5S DNAs and one minor oocyte-specific 5S DNA.

Authors: R C Peterson; J L Doering; D D Brown
Journal: Cell Date: 1980-05 Impact factor: 41.582

9. Chemical probes for higher-order structure in RNA.

Authors: D A Peattie; W Gilbert
Journal: Proc Natl Acad Sci U S A Date: 1980-08 Impact factor: 11.205

10. Interaction of bleomycin with DNA.

Authors: M Takeshita; A P Grollman; E Ohtsubo; H Ohtsubo
Journal: Proc Natl Acad Sci U S A Date: 1978-12 Impact factor: 11.205

6 in total

1. Correlation of Thermal Stability and Structural Distortion of DNA Interstrand Cross-Links Produced from Oxidized Abasic Sites with Their Selective Formation and Repair.

Authors: Souradyuti Ghosh; Marc M Greenberg
Journal: Biochemistry Date: 2015-10-01 Impact factor: 3.162

2. Altered cleavage of DNA sequences by bleomycin and its deglycosylated derivative in the presence of actinomycin.

Authors: C Bailly; A Kénani; M J Waring
Journal: Nucleic Acids Res Date: 1997-04-15 Impact factor: 16.971

3. Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription.

Authors: W Giffin; W Gong; C Schild-Poulter; R J Haché
Journal: Mol Cell Biol Date: 1999-06 Impact factor: 4.272