Literature DB >> 12698269

Protective mechanisms against the antitumor agent bleomycin: lessons from Saccharomyces cerevisiae.

Dindial Ramotar1, Huijie Wang.   

Abstract

Bleomycin is a small glycopeptide antibiotic used in combination therapy for the treatment of a few types of human cancer. The antitumor effect of bleomycin is most likely caused by its ability to bind to DNA and induce the formation of toxic DNA lesions via a free radical reactive (Fe.bleomycin) complex. However, the chemotherapeutic potential of bleomycin is limited, as it causes pulmonary fibrosis and tumor resistance at high doses. The chemical structure and modes of action of bleomycin have been extensively studied and these provide a foundation towards improving the therapeutic value of the drug. This review provides a first account of the current state of knowledge of the cellular processes that can allow the yeast Saccharomyces cerevisiae to evade the lethal effects of bleomycin. This model organism is likely to provide rapid clues in our understanding of bleomycin resistance in tumor cells.

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Year:  2003        PMID： 12698269     DOI： 10.1007/s00294-003-0396-1

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  159 in total

1.  Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage.

Authors:  A Jilani; D Ramotar; C Slack; C Ong; X M Yang; S W Scherer; D D Lasko
Journal:  J Biol Chem       Date:  1999-08-20       Impact factor: 5.157

2.  A role for Saccharomyces cerevisiae histone H2A in DNA repair.

Authors:  J A Downs; N F Lowndes; S P Jackson
Journal:  Nature       Date:  2000 Dec 21-28       Impact factor: 49.962

3.  Cleavage of Nucleic Acids by Bleomycin.

Authors:  Richard M. Burger
Journal:  Chem Rev       Date:  1998-05-07       Impact factor: 60.622

4.  A model for p53-induced apoptosis.

Authors:  K Polyak; Y Xia; J L Zweier; K W Kinzler; B Vogelstein
Journal:  Nature       Date:  1997-09-18       Impact factor: 49.962

5.  Breaks and rejoining of DNA in cultured mammalian cells treated with bleomycin.

Authors:  T Terasima; M Yasukawa; H Umezawa
Journal:  Gan       Date:  1970-10

6.  Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1.

Authors:  B Philip; D E Levin
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

7.  Cellular resistance to bleomycin in Saccharomyces cerevisiae is not affected by changes in bleomycin hydrolase levels.

Authors:  Hujie Wang; Dindial Ramotar
Journal:  Biochem Cell Biol       Date:  2002       Impact factor: 3.626

8.  Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.

Authors:  R E Johnson; C A Torres-Ramos; T Izumi; S Mitra; S Prakash; L Prakash
Journal:  Genes Dev       Date:  1998-10-01       Impact factor: 11.361

9.  Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.

Authors:  F Rossi; E Labourier; T Forné; G Divita; J Derancourt; J F Riou; E Antoine; G Cathala; C Brunel; J Tazi
Journal:  Nature       Date:  1996-05-02       Impact factor: 49.962

10.  Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane.

Authors:  A Decottignies; L Lambert; P Catty; H Degand; E A Epping; W S Moye-Rowley; E Balzi; A Goffeau
Journal:  J Biol Chem       Date:  1995-07-28       Impact factor: 5.157
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  17 in total

1.  Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions.

Authors:  C K Haston; T G Tomko; N Godin; L Kerckhoff; M T Hallett
Journal:  J Med Genet       Date:  2005-06       Impact factor: 6.318

2.  Does single-dose cell resistance to the radio-mimetic zeocin correlate with a zeocin-induced adaptive response in Chlamydomonas reinhardtii strains?

Authors:  E Dimova; M Dimitrova; D Miteva; Z Mitrovska; N P Yurina; P E Bryant; S Chankova
Journal:  Radiat Environ Biophys       Date:  2008-10-28       Impact factor: 1.925

3.  Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae.

Authors:  Brian M Wasko; Cory L Holland; Michael A Resnick; L Kevin Lewis
Journal:  DNA Repair (Amst)       Date:  2008-11-18

4.  Characterization of a transport and detoxification pathway for the antitumour drug bleomycin in Saccharomyces cerevisiae.

Authors:  Mustapha Aouida; Anick Leduc; Huijie Wang; Dindial Ramotar
Journal:  Biochem J       Date:  2004-11-15       Impact factor: 3.857

5.  INO80 Chromatin Remodeler Facilitates Release of RNA Polymerase II from Chromatin for Ubiquitin-Mediated Proteasomal Degradation.

Authors:  Anne Lafon; Surayya Taranum; Federico Pietrocola; Florent Dingli; Damarys Loew; Sandipan Brahma; Blaine Bartholomew; Manolis Papamichos-Chronakis
Journal:  Mol Cell       Date:  2015-11-19       Impact factor: 17.970

6.  Isolation and characterization of Saccharomyces cerevisiae mutants with enhanced resistance to the anticancer drug bleomycin.

Authors:  Mustapha Aouida; Omar Tounekti; Anick Leduc; Omrane Belhadj; Lluis Mir; Dindial Ramotar
Journal:  Curr Genet       Date:  2004-03-09       Impact factor: 3.886

7.  Differential requirements for RAD51 in Physcomitrella patens and Arabidopsis thaliana development and DNA damage repair.

Authors:  Ulrich Markmann-Mulisch; Edelgard Wendeler; Oliver Zobell; Gabriele Schween; Hans-Henning Steinbiss; Bernd Reiss
Journal:  Plant Cell       Date:  2007-10-05       Impact factor: 11.277

8.  Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.

Authors:  Brietta L Pike; Jörg Heierhorst
Journal:  Mol Cell Biol       Date:  2007-07-16       Impact factor: 4.272

9.  The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.

Authors:  Mustapha Aouida; Richard Poulin; Dindial Ramotar
Journal:  J Biol Chem       Date:  2009-12-25       Impact factor: 5.157

10.  A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae.

Authors:  Jennifer Summers McKinney; Sunaina Sethi; Jennifer DeMars Tripp; Thuy N Nguyen; Brian A Sanderson; James W Westmoreland; Michael A Resnick; L Kevin Lewis
Journal:  BMC Genomics       Date:  2013-04-15       Impact factor: 3.969
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