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Literature DB >> 6170983

DNA sequence of a major human leukocyte interferon gene.

R M Lawn, M Gross, C M Houck, A E Franke, P V Gray, D V Goeddel.

Abstract

The gene for human leukocyte interferon alpha 2 (designated either LeIF A or HuIFN-alpha 2) has been isolated from a human genome library. The DNA sequence of this gene demonstrates that it lacks introns. The 3' noncoding sequences of the IFN-alpha 2 gene correspond to two types of IFN-alpha 2 cDNA clones we have isolated that have alternate sites of polyadenylylation. A comparison of seven human IFN-alpha sequences shows that they are homologous in the 5' flanking region and contain identical "TATA box" sequences. The recombinant lambda clone containing the IFN-alpha 2 gene also contains two copies of the "Alu family" repeat sequence.

Entities: Gene Species

Mesh：

Substances：

Year: 1981 PMID： 6170983 PMCID： PMC348760 DOI： 10.1073/pnas.78.9.5435

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

36 in total

1. Molecular cloning and characterization of the human beta-like globin gene cluster.

Authors: E F Fritsch; R M Lawn; T Maniatis
Journal: Cell Date: 1980-04 Impact factor: 41.582

2. A simple method for DNA restriction site mapping.

Authors: H O Smith; M L Birnstiel
Journal: Nucleic Acids Res Date: 1976-09 Impact factor: 16.971

3. Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.

Authors: R Grosschedl; M L Birnstiel
Journal: Proc Natl Acad Sci U S A Date: 1980-03 Impact factor: 11.205

4. Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences.

Authors: C M Rubin; C M Houck; P L Deininger; T Friedmann; C W Schmid
Journal: Nature Date: 1980-03-27 Impact factor: 49.962

5. Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors: A M Maxam; W Gilbert
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

6. Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes.

Authors: B Wasylyk; C Kédinger; J Corden; O Brison; P Chambon
Journal: Nature Date: 1980-06-05 Impact factor: 49.962

7. The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors: R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal: Cell Date: 1978-12 Impact factor: 41.582

8. Synthesis in E. coli of a polypeptide with human leukocyte interferon activity.

Authors: S Nagata; H Taira; A Hall; L Johnsrud; M Streuli; J Ecsödi; W Boll; K Cantell; C Weissmann
Journal: Nature Date: 1980-03-27 Impact factor: 49.962

9. Ubiquitous, interspersed repeated sequences in mammalian genomes.

Authors: W R Jelinek; T P Toomey; L Leinwand; C H Duncan; P A Biro; P V Choudary; S M Weissman; C M Rubin; C M Houck; P L Deininger; C W Schmid
Journal: Proc Natl Acad Sci U S A Date: 1980-03 Impact factor: 11.205

10. The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.

Authors: J Lauer; C K Shen; T Maniatis
Journal: Cell Date: 1980-05 Impact factor: 41.582

17 in total

1. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

Authors: D J Capon; H M Shepard; D V Goeddel
Journal: Mol Cell Biol Date: 1985-04 Impact factor: 4.272

DNA sequence of a major human leukocyte interferon gene.

1. Molecular cloning and characterization of the human beta-like globin gene cluster.

2. A simple method for DNA restriction site mapping.

3. Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.

4. Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences.

5. Sequencing end-labeled DNA with base-specific chemical cleavages.

6. Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes.

7. The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

8. Synthesis in E. coli of a polypeptide with human leukocyte interferon activity.

9. Ubiquitous, interspersed repeated sequences in mammalian genomes.

10. The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.

1. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

2. Sequence-directed mutagenesis: evidence from a phylogenetic history of human alpha-interferon genes.

3. Unusually long mRNA species coding for human alpha and beta interferons.

4. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

5. Organization, structure and expression of murine interferon alpha genes.

6. Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes.

7. Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase.

8. The primary structure of the larval beta 1-globin gene of Xenopus laevis and its flanking regions.

9. Optimization of gene expression in Streptomyces lividans by a transcription terminator.

10. Structure and expression of cloned murine IFN-alpha genes.