Literature DB >> 2987811

Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes.

K A Kelley, P M Pitha.   

Abstract

A BALB/c mouse genomic library was screened with a murine interferon alpha 2 (MuIFN-alpha 2) cDNA coding region fragment. Eight clones were isolated which contain different mouse chromosomal segments related to the MuIFN-alpha 2 probe and a 28 kilobase (kb) region of mouse genomic DNA containing four different MuIFN-alpha genes (alpha 1, alpha 4, alpha 5 and alpha 6) was identified and characterized; an intergenic 1000 nucleotide long conserved sequence was found to be associated with three of these four alpha genes, indicating that this alpha-IFN gene cluster evolved through tandem duplications. Sequence analysis revealed the absence of a polyadenylation site in the 3' untranslated region of MuIFN-alpha 1, and showed that one of the genes (alpha 4) contains an internal deletion of 5 amino acids in the coding region.

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Year:  1985        PMID： 2987811      PMCID： PMC341036          DOI： 10.1093/nar/13.3.805

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  34 in total

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4.  Construction and characterization of the hybrid bacteriophage lambda Charon vectors for DNA cloning.

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5.  Screening lambdagt recombinant clones by hybridization to single plaques in situ.

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Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

6.  Involvement of a gene on chromosome 9 in human fibroblast interferon production.

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7.  3' non-coding region sequences in eukaryotic messenger RNA.

Authors:  N J Proudfoot; G G Brownlee
Journal:  Nature       Date:  1976-09-16       Impact factor: 49.962

8.  A simple method for DNA restriction site mapping.

Authors:  H O Smith; M L Birnstiel
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Authors:  Y H Tan; F Barakat; W Berthold; H Smith-Johannsen; C Tan
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10.  Linkage analysis of the murine interferon-alpha locus on chromosome 4.

Authors:  F Dandoy; K A Kelley; J DeMaeyer-Guignard; E DeMaeyer; P M Pitha
Journal:  J Exp Med       Date:  1984-07-01       Impact factor: 14.307
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  16 in total

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Journal:  J Virol       Date:  1986-06       Impact factor: 5.103

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6.  Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7.

Authors:  I Marié; J E Durbin; D E Levy
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9.  Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db).

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10.  Genetic map of rat chromosome 5 including the fatty (fa) locus.

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