Literature DB >> 6167986

Partial characterization of gamma (immune) interferon mRNA extracted from human lymphocytes.

T Taniguchi, R H Pang, Y K Yip, D Henriksen, J Vilcek.   

Abstract

gamma (immune) interferon (IFN-gamma) was induced in cultures of fresh human lymphocytes by combined treatment with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and the T cell mitogen phytohemagglutinin (PHA). Compared to the IFN-gamma yields obtained with PHA induction alone, the inclusion of TPA caused a significant enhancement of IFN-gamma production. Poly(A)-containing mRNA was isolated from mononuclear cells induced with TPA and PHA. Injected into Xenopus laevis oocytes, this mRNA preparation gave rise to IFN activity with characteristic properties of human IFN-gamma. Sucrose density gradient centrifugation analysis showed that IFN-gamma mRNA sedimented at 15 S, suggesting that it contains a total of about 1400 nucleotides.

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Year:  1981        PMID： 6167986      PMCID： PMC319590          DOI： 10.1073/pnas.78.6.3469

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Cell-free synthesis of human interferon.

Authors:  S Pestka; J McInnes; E A Havell; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

2.  Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system.

Authors:  M N Thang; D C Thang; E De Maeyer; L Montagnier
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

3.  Interferon messenger RNA content of human fibroblasts during induction, shutoff, and superinduction of interferon production.

Authors:  P B Sehgal; B Dobberstein; I Tamm
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

4.  Phorbol myristic acetate stimulates LAF production by the macrophage cell line, P388D.

Authors:  S B Mizel; D L Rosenstreich; J J Oppenheim
Journal:  Cell Immunol       Date:  1978-09-15       Impact factor: 4.868

5.  Superinduction of human fibroblast interferon production: further evidence for increased stability of interferon mRNA.

Authors:  P B Sehgal; D S Lyles; I Tamm
Journal:  Virology       Date:  1978-08       Impact factor: 3.616

6.  Inhibition of intractable nucleases with ribonucleoside--vanadyl complexes: isolation of messenger ribonucleic acid from resting lymphocytes.

Authors:  S L Berger; C S Birkenmeier
Journal:  Biochemistry       Date:  1979-11-13       Impact factor: 3.162

7.  Interferon messenger RNA: translation in heterologous cells.

Authors:  J de Maeyer-Guignard; E de Maeyer; L Montagnier
Journal:  Proc Natl Acad Sci U S A       Date:  1972-05       Impact factor: 11.205

8.  Attempts to induce interferon production by IdUrd induction and EBV superinfection in human lymphoma lines and their hybrids.

Authors:  G Klein; J Vilcek
Journal:  J Gen Virol       Date:  1980-01       Impact factor: 3.891

9.  Partial purification and characterization of human gamma (immune) interferon.

Authors:  Y K Yip; R H Pang; C Urban; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

10.  Synthesis of human interferon by Xenopus laevis oocytes: two structural genes for interferons in human cells.

Authors:  R L Cavalieri; E A Havell; J Vilcek; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205
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  8 in total

1.  Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells.

Authors:  S Ohno; T Taniguchi
Journal:  Nucleic Acids Res       Date:  1982-02-11       Impact factor: 16.971

2.  Structure of the human interleukin 2 gene.

Authors:  T Fujita; C Takaoka; H Matsui; T Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

3.  Combination therapy of cyclosporine with steroid inhibits gamma-interferon and interleukin-1 gene expression at the level of mRNA synthesis in vivo.

Authors:  N Yoshimura; T Oka; M Kita; H Teraoka; Y Hirai
Journal:  J Clin Immunol       Date:  1989-07       Impact factor: 8.317

4.  Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.

Authors:  R Devos; H Cheroutre; Y Taya; W Degrave; H Van Heuverswyn; W Fiers
Journal:  Nucleic Acids Res       Date:  1982-04-24       Impact factor: 16.971

5.  Stimulation of human gamma interferon production by diterpene esters.

Authors:  Y K Yip; R H Pang; J D Oppenheim; M S Nachbar; D Henriksen; I Zerebeckyj-Eckhardt; J Vilcek
Journal:  Infect Immun       Date:  1981-10       Impact factor: 3.441

6.  Interleukin-2 receptor gene expression in kidney transplant recipients treated with cyclosporin A.

Authors:  N Yoshimura; T Oka; T Amagai; Y Horii; J Imanishi
Journal:  Clin Exp Immunol       Date:  1991-08       Impact factor: 4.330

7.  Quantitative analysis of integrated Ed alpha gene expression in C57BL/6 transgenic mice.

Authors:  S I Kashiwamura; Y Sadakane; H Kikutani; T Kishimoto; M Kimoto
Journal:  Immunology       Date:  1988-12       Impact factor: 7.397

8.  Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.

Authors:  G Buchan; K Barrett; T Fujita; T Taniguchi; R Maini; M Feldmann
Journal:  Clin Exp Immunol       Date:  1988-02       Impact factor: 4.330
  8 in total

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