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Literature DB >> 6158050

Predicting coding function from nucleotide sequence or survival of "fitness" of tRNA.

Abstract

The sequence of a nucleotide region of f1 bacteriophage was determined on a bonded ultrathin acrylamide gel with a discontinuous buffer system by using the dideoxy-DNA sequencing method. This sequence and one other were analyzed for maximal base pairing with tRNAs. The results allow a prediction of the direction and phase of possible coding functions. The implication of sequence constraints on mRNA codon frequency, tRNA structure, the origin of protein synthesis, and triplet reading are discussed in terms of neutral, Darwinian, and genotypic selectionist perspectives of evolution. The model of F. H. C. Crick, S. Brenner, A. Klug, and G. Pieczenik [(1976) Origins of Life 7, 389-397] for the origin of the genetic code is used to interpet contemporary adaptive and functional nucleic acid sequences.

Entities: Chemical Species

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Year: 1980 PMID： 6158050 PMCID： PMC349652 DOI： 10.1073/pnas.77.6.3539

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

2. Influence of modification next to the anticodon in tRNA on codon context sensitivity of translational suppression and accuracy.

Authors: F Bouadloun; T Srichaiyo; L A Isaksson; G R Björk
Journal: J Bacteriol Date: 1986-06 Impact factor: 3.490

Predicting coding function from nucleotide sequence or survival of "fitness" of tRNA.

1. A mutation of the wobble nucleotide of a bacteriophage T4 transfer RNA.

2. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

3. Use of the UGA terminator as a tryptophan codon in yeast mitochondria.

4. Nucleotide sequences near the origin of replication of bacteriophage f1.

5. Mapping of bacteriophage f1 ribosome binding sites to their cognate genes.

6. Determination of a nucleotide sequence in bacteriophage f1 DNA by primed synthesis with DNA polymerase.

7. Bacteriophage phi 80-induced low molecular weight RNA.

8. Protein polymorphism as a phase of molecular evolution.

9. The use of thin acrylamide gels for DNA sequencing.

10. DNA sequencing with chain-terminating inhibitors.

1. Evolution of monoblepharidalean fungi based on complete mitochondrial genome sequences.

2. Influence of modification next to the anticodon in tRNA on codon context sensitivity of translational suppression and accuracy.

3. Does the 'non-coding' strand code?

4. Strong doublet preferences in nucleotide sequences and DNA geometry.

5. Expected frequencies of codon use as a function of mutation rates and codon fitnesses.

6. Nucleotide sequence of bacteriophage f1 DNA.