Literature DB >> 2538104

Inhibition of polymorphonuclear leucocyte functions in vivo by Yersinia enterocolitica lipopolysaccharide.

K T Hartiala1, I Granberg, A Toivanen, M Viljanen.   

Abstract

A single intravenous injection of 5 micrograms of Yersinia enterocolitica lipopolysaccharide (LPS) inhibits rabbit polymorphonuclear leucocyte (PMN) chemotaxis, enzyme secretion, and respiratory burst activation in response to partially purified rabbit C5a and leucotriene B4 (LTB4). Respiratory burst activation is also inhibited in response to platelet activating factor (PAF). In contrast, all these responses to n-formyl-methionyl-leucyl-phenylalanine (FMLP) remain unaltered. This LPS does not modulate PMN activation in vitro or activate the respiratory burst. Thus Y enterocolitica LPS acts in vivo by inhibiting PMN responses to endogenous mediators of inflammation. This inhibition presumably impairs the elimination of pathogens and might, therefore, provide favourable conditions for induction by bacteria of further immunological consequences.

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Year:  1989        PMID： 2538104      PMCID： PMC1003673          DOI： 10.1136/ard.48.1.42

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  28 in total

1.  QUANTITATIVE ASPECTS OF THE PYROGENIC RESPONSE OF RABBITS TO ENDOTOXIN.

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Journal:  J Lab Clin Med       Date:  1965-02

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Authors:  D C Morrison; R J Ulevitch
Journal:  Am J Pathol       Date:  1978-11       Impact factor: 4.307

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Authors:  J M Lynch; G Z Lotner; S J Betz; P M Henson
Journal:  J Immunol       Date:  1979-09       Impact factor: 5.422

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Authors:  H R Kimball; M L Melmon; S M Wolff
Journal:  Proc Soc Exp Biol Med       Date:  1972-03

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Authors:  D C Morrison; L F Kline
Journal:  J Immunol       Date:  1977-01       Impact factor: 5.422

7.  Endotoxin-induced uveitis in rats as a model for human disease.

Authors:  J T Rosenbaum; H O McDevitt; R B Guss; P R Egbert
Journal:  Nature       Date:  1980-08-07       Impact factor: 49.962

8.  A specific inhibitor of complement (C5)-derived chemotactic activity in serum from patients with systemic lupus erythematosus.

Authors:  H D Perez; M Lipton; I M Goldstein
Journal:  J Clin Invest       Date:  1978-07       Impact factor: 14.808

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Authors:  S H Zigmond; J G Hirsch
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307

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Journal:  Yale J Biol Med       Date:  1967-12
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  2 in total

1.  Comparative study of histopathological alterations during intestinal infection of mice with pathogenic and non-pathogenic strains of Yersinia enterocolitica serotype O:8.

Authors:  A Grützkau; C Hanski; M Naumann
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1993

2.  Humoral and cellular defense against intestinal murine infection with Yersinia enterocolitica.

Authors:  C Hanski; M Naumann; A Grützkau; G Pluschke; B Friedrich; H Hahn; E O Riecken
Journal:  Infect Immun       Date:  1991-03       Impact factor: 3.441
  2 in total

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