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Literature DB >> 6154931

Structure of the alpha-fetoprotein gene in the mouse.

Abstract

The mouse alpha-fetoprotein mRNA is the product of a single-copy gene whose mRNA coding sequences are represented discontinuously in the genome. Several EcoRI genomic fragments which contain portions of the alpha-fetoprotein gene have been cloned using the EK2 vector lambda gt WES . lambda B. In addition, a mouse genomic library has been screened to obtain a 15.75-kilobase segment of DNA that includes more than 85% of the alpha-fetoprotein coding sequence. Analyses by restriction endonuclease mapping and electron microscopy showed that the mRNA sequence is interrupted by at least 11 intervening sequences which occupy 90% of the cloned DNA.

Entities: Gene Species

Mesh：

Substances：

Year: 1980 PMID： 6154931 PMCID： PMC348492 DOI： 10.1073/pnas.77.3.1351

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

29 in total

1. Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

Authors: M Grunstein; D S Hogness
Journal: Proc Natl Acad Sci U S A Date: 1975-10 Impact factor: 11.205

2. Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis.

Authors: T Maniatis; A Jeffrey; H van deSande
Journal: Biochemistry Date: 1975-08-26 Impact factor: 3.162

3. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

4. Serum alpha-fetoprotein, albumin, and gamma-G-globulin in the human conceptus.

Authors: D Gitlin; M Boesman
Journal: J Clin Invest Date: 1966-11 Impact factor: 14.808

5. Alpha-fetoprotein: immunochemical purification and chemical properties. Expression in normal state and in malignant and non-malignant liver disease.

Authors: E Ruoslahti; H Pihko; M Seppälä
Journal: Transplant Rev Date: 1974

6. Alpha-fetoprotein as a marker of embryo-specific differentiations in normal and tumor tissues.

Authors: G I Abelev
Journal: Transplant Rev Date: 1974

7. Cell-free studies of developmental changes in synthesis of alpha-foetoprotein and albumin in the mouse liver.

Authors: T Tamaoki; K Thomas; I Schindler
Journal: Nature Date: 1974-05-17 Impact factor: 49.962

8. Embryonal serum alpha-globulin in cancer patients: diagnostic value.

Authors: G I Abelev; I V Assecritova; N A Kraevsky; S D Perova; N I Perevodchikova
Journal: Int J Cancer Date: 1967-09-15 Impact factor: 7.396

9. Nucleotide sequence of the rightward operator of phage lambda.

Authors: T Maniatis; A Jeffrey; D G Kleid
Journal: Proc Natl Acad Sci U S A Date: 1975-03 Impact factor: 11.205

10. Viable molecular hybrids of bacteriophage lambda and eukaryotic DNA.

Authors: M Thomas; J R Cameron; R W Davis
Journal: Proc Natl Acad Sci U S A Date: 1974-11 Impact factor: 11.205

13 in total

1. Replication program of active and inactive multigene families in mammalian cells.

Authors: K S Hatton; V Dhar; E H Brown; M A Iqbal; S Stuart; V T Didamo; C L Schildkraut
Journal: Mol Cell Biol Date: 1988-05 Impact factor: 4.272

2. Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.

Authors: L L Jagodzinski; T D Sargent; M Yang; C Glackin; J Bonner
Journal: Proc Natl Acad Sci U S A Date: 1981-06 Impact factor: 11.205

3. Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation.

Authors: P R Young; S M Tilghman
Journal: Mol Cell Biol Date: 1984-05 Impact factor: 4.272

Structure of the alpha-fetoprotein gene in the mouse.

1. Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

2. Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis.

3. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

4. Serum alpha-fetoprotein, albumin, and gamma-G-globulin in the human conceptus.

5. Alpha-fetoprotein: immunochemical purification and chemical properties. Expression in normal state and in malignant and non-malignant liver disease.

6. Alpha-fetoprotein as a marker of embryo-specific differentiations in normal and tumor tissues.

7. Cell-free studies of developmental changes in synthesis of alpha-foetoprotein and albumin in the mouse liver.

8. Embryonal serum alpha-globulin in cancer patients: diagnostic value.

9. Nucleotide sequence of the rightward operator of phage lambda.

10. Viable molecular hybrids of bacteriophage lambda and eukaryotic DNA.

1. Replication program of active and inactive multigene families in mammalian cells.

2. Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.

3. Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation.

4. Fine structure and evolution of the rat serum albumin gene.

5. Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement.

6. Mechanisms by which eucaryotic genes evolve.

7. The chromosomal distribution of repetitive DNA sequences within the human beta globin gene cluster.

8. Acute treatment of mice with cadmium salts results in amplification of the metallothionein-1 gene in liver.

9. raf regulates the postnatal repression of the mouse alpha-fetoprotein gene at the posttranscriptional level.

10. alpha-Fetoprotein and albumin genes are in tandem in the mouse genome.