Literature DB >> 6150866

Hypothalamic tyrosine hydroxylase activity, plasma gonadotropin and prolactin levels after aminooxyacetic acid in ovariectomized rats.

G N Babu, E Vijayan.   

Abstract

Plasma concentrations of gonadotropin, prolactin and hypothalamic tyrosine hydroxylase (TH) activity were measured in ovariectomized rats treated with aminooxyacetic acid (AOAA), a drug which elevates brain GABA levels. Hypothalamic TH activity was significantly increased with a significant decrease in prolactin (Prl) release. Plasma levels of gonadotropins were not modified by AOAA. These results support an inhibitory action of GABA on Prl release possibly mediated through hypothalamic dopamine.

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Year:  1984        PMID： 6150866     DOI： 10.1007/BF01951923

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  In vivo incorporation of L-(3H)arginine into proteins of anterior pituitary gland and hypothalamus of intact and castrated rats.

Authors:  E Vijayan
Journal:  Brain Res       Date:  1974-06-07       Impact factor: 3.252

2.  The role of GABA metabolism in the convulsant and anticonvulsant actions of aminooxyacetic acid.

Authors:  J D Wood; S J Peesker
Journal:  J Neurochem       Date:  1973-02       Impact factor: 5.372

3.  Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla.

Authors:  R Shiman; M Akino; S Kaufman
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

4.  GABA and gonadal hormones.

Authors:  C J Earley; B E Leonard
Journal:  Brain Res       Date:  1978-10-20       Impact factor: 3.252

5.  Current concepts: II. Effect of aminooxyacetic acid and bicuculline on prolactin release in castrated male rats.

Authors:  L Debeljuk; S Goijman; A Seilicovich; M C Díaz; V B Rettori
Journal:  Life Sci       Date:  1980-12-01       Impact factor: 5.037

6.  Effects of 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD 1) on the central nervous system: (2) Effects on nigro-striatal dopaminergic neurons.

Authors:  K Toide; K Kitazato; N Unemi
Journal:  Arch Int Pharmacodyn Ther       Date:  1981-07

7.  Gamma-aminobutyric acid effects on pituitary gonadotropin secretion.

Authors:  J G Ondo
Journal:  Science       Date:  1974-11-22       Impact factor: 47.728

8.  The effects of intraventricular injection of gamma-aminobutyric acid (GABA) on prolactin and gonadotropin release in conscious female rats.

Authors:  E Vijayan; S M McCann
Journal:  Brain Res       Date:  1978-10-20       Impact factor: 3.252

9.  The effects of gamma-aminobutyric acid on prolactin and gonadotropin secretion in the unanesthetized rat.

Authors:  K A Pass; J G Ondo
Journal:  Endocrinology       Date:  1977-05       Impact factor: 4.736

10.  The effect of intraventricular gamma aminobutyric acid (GABA) on hypothalamic catecholamines and LHRH and on pituitary hormone release.

Authors:  A Negro-Vilar; E Vijayan; S M McCann
Journal:  Brain Res Bull       Date:  1980 May-Jun       Impact factor: 4.077
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