Literature DB >> 849735

The effects of gamma-aminobutyric acid on prolactin and gonadotropin secretion in the unanesthetized rat.

K A Pass, J G Ondo.   

Abstract

The effects of the intraventricular injection of gamma-aminobutyric acid (GABA) on pituitary secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin (PRL) were examined in Na-pentobarbital (PB)-anesthetized and unanesthetized male rats. GABA (5 or 10 millimicronmol) injected into the lateral ventricle of PB anesthetized rats resulted in significant elevations in plasma concentrations of LH and PRL. When administered via a lateral ventricle cannula to unanesthetized rats, GABA (1, 5, or 10 millimicronmol) caused a significant increase in plasma PRL levels but had no effect on plasm LH concentrations. Plasma FSH was uninfluenced by GABA in all animals studied. The data indicate that PB anesthesia can alter the hypothalamic pituitary axis to a possible neurotransmitter agent.

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Year:  1977        PMID： 849735     DOI： 10.1210/endo-100-5-1437

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  11 in total

1.  Involvement of endogenous gabaergic system in the modulation of gonadotropin secretion in normal cycling women.

Authors:  G B Melis; V Mais; A M Paoletti; F Beneventi; F D Petacchi; P Fioretti
Journal:  J Endocrinol Invest       Date:  1986-02       Impact factor: 4.256

2.  Morphological evidence for a direct neuroendocrine GABAergic control of the anterior pituitary in teleosts.

Authors:  O Kah; P Dubourg; M G Martinoli; M Geffard; A Calas
Journal:  Experientia       Date:  1987-03-15

3.  Effect of long-term treatment with sodium valproate on gonadotrophin and prolactin secretion in paediatric patients.

Authors:  A Masala; T Meloni; S Alagna; P P Rovasio; S Rassu; G Mele; V Franca
Journal:  Br J Clin Pharmacol       Date:  1981-12       Impact factor: 4.335

4.  Role of substance P in suppressing growth hormone release in the rat.

Authors:  M Arisawa; G D Snyder; L De Palatis; R H Ho; R K Xu; G Pan; S M McCann
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

5.  Estriol affects prolactin and LH secretion in rats.

Authors:  M C Diaz; A Seilicovich; B H Duvilanski; N Siseles; M Lasaga; L Debeljuk
Journal:  J Endocrinol Invest       Date:  1989-01       Impact factor: 4.256

6.  Central GABAergic innervation of neurointermediate pituitary lobe: biochemical and immunocytochemical study in the rat.

Authors:  W H Oertel; E Mugnaini; M L Tappaz; V K Weise; A L Dahl; D E Schmechel; I J Kopin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

7.  Anatomical relationships of dopaminergic and GABAergic systems with the GnRH-systems in the septo-hypothalamic area. Immunohistochemical studies.

Authors:  L Jennes; W E Stumpf; M L Tappaz
Journal:  Exp Brain Res       Date:  1983       Impact factor: 1.972

Review 8.  Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications.

Authors:  E E Müller; V Locatelli; S Cella; A Peñalva; A Novelli; D Cocchi
Journal:  Drugs       Date:  1983-04       Impact factor: 9.546

9.  Hypothalamic tyrosine hydroxylase activity, plasma gonadotropin and prolactin levels after aminooxyacetic acid in ovariectomized rats.

Authors:  G N Babu; E Vijayan
Journal:  Experientia       Date:  1984-12-15

10.  Involvement of preoptic-anterior hypothalamic GABA neurons in the regulation of pituitary LH and prolactin release.

Authors:  R Lamberts; E Vijayan; M Graf; T Mansky; W Wuttke
Journal:  Exp Brain Res       Date:  1983       Impact factor: 1.972
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