| Literature DB >> 6145763 |
J D Smart, I W Kellaway, H E Worthington.
Abstract
An in-vitro test system was developed to investigate the adhesiveness of various materials to mucus. The results obtained showed good agreement with the findings of previous in-vivo evaluations of mucosa-adhesives. Further investigations found that these materials become adhesive on hydration. Chain length, and the presence of ionizable groups in the molecule, were found to be determinate factors. The physical nature of the gel, and the location at which the mucoadhesive materials hydrated, were of less importance.Entities:
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Year: 1984 PMID： 6145763 DOI： 10.1111/j.2042-7158.1984.tb04377.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765