Literature DB >> 6140920

Glutamine synthetase activity of muscle in acidosis.

P A King, L Goldstein, E A Newsholme.   

Abstract

Metabolic acidosis stimulates the rate of glutamine release from muscle, and this in turn is used by the kidney in acid-base balance. NH4Cl, HCl or diabetic ketoacidosis increases the maximum activity of glutamine synthetase in skeletal muscle. Starvation and administration of adrenal steroids also increase the activity of the enzyme in muscle.

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Year:  1983        PMID: 6140920      PMCID: PMC1152536          DOI: 10.1042/bj2160523

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  10 in total

Review 1.  Amino acid metabolism in man.

Authors:  P Felig
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

2.  Chinese hamster liver glutamine synthetase. Purification, physical and biochemical properties.

Authors:  D C Tiemeier; G Milman
Journal:  J Biol Chem       Date:  1972-04-25       Impact factor: 5.157

3.  Plasma amino acid levels in diabetic ketoacidosis.

Authors:  P Felig; E Marliss; J L Ohman; C F Cahill
Journal:  Diabetes       Date:  1970-10       Impact factor: 9.461

4.  Glutamine synthetase induction by glucocorticoids in the glucocorticoid-sensitive human leukemic cell line CEM-C7.

Authors:  J M Harmon; E B Thompson
Journal:  J Cell Physiol       Date:  1982-02       Impact factor: 6.384

5.  A radiochemical assay for glutamine synthetase, and activity of the enzyme in rat tissues.

Authors:  P Lund
Journal:  Biochem J       Date:  1970-06       Impact factor: 3.857

6.  Muscle glutamine production in diabetic ketoacidotic rats.

Authors:  L Goldstein; D F Perlman; P M McLaughlin; P A King; C J Cha
Journal:  Biochem J       Date:  1983-09-15       Impact factor: 3.857

7.  Glutamine synthetase in muscle and kidney.

Authors:  K Iqbal; J H Ottaway
Journal:  Biochem J       Date:  1970-09       Impact factor: 3.857

8.  Experimental diabetic ketoacidosis. Sequential changes of metabolic intermediates in blood, liver, cerebrospinal fluid and brain after acute insulin deprivation in the streptozotocin-diabetic rat.

Authors:  P J Blackshear; K G Alberti
Journal:  Biochem J       Date:  1974-01       Impact factor: 3.857

9.  Glutamine release from hindlimb and uptake by kidney in the acutely acidotic rat.

Authors:  H Schröck; C J Cha; L Goldstein
Journal:  Biochem J       Date:  1980-05-15       Impact factor: 3.857

10.  Interorgan relationships for glutamine metabolism in normal and acidotic rats.

Authors:  H Schröck; L Goldstein
Journal:  Am J Physiol       Date:  1981-05
  10 in total
  11 in total

1.  Effects of changes in cell volume on the rates of glutamine and alanine release from rat skeletal muscle in vitro.

Authors:  M Parry-Billings; S J Bevan; E Opara; E A Newsholme
Journal:  Biochem J       Date:  1991-06-01       Impact factor: 3.857

2.  The possible role of glutamine substrate cycles in skeletal muscle.

Authors:  M Parry-Billings; E A Newsholme
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857

3.  Distribution of glutamine synthetase in the snapper (Pagrus auratus) and implications for the immune system.

Authors:  S P Walker; D Keast; S McBride
Journal:  Fish Physiol Biochem       Date:  1996-06       Impact factor: 2.794

4.  The effect of ketone bodies on alanine and glutamine metabolism in isolated skeletal muscle from the fasted chick.

Authors:  G Y Wu; J R Thompson
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

5.  Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation.

Authors:  Pham Nguyen Quy; Akiko Kuma; Philippe Pierre; Noboru Mizushima
Journal:  J Biol Chem       Date:  2012-12-03       Impact factor: 5.157

Review 6.  The emerging role of glutamine as an indicator of exercise stress and overtraining.

Authors:  D G Rowbottom; D Keast; A R Morton
Journal:  Sports Med       Date:  1996-02       Impact factor: 11.136

7.  Glutamine metabolism in skeletal muscles from the broiler chick (Gallus domesticus) and the laboratory rat (Rattus norvegicus)

Authors:  G Y Wu; J R Thompson; V E Baracos
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857

8.  Physiological glucocorticoid levels regulate glutamine and insulin-mediated glucose metabolism in skeletal muscle of the rat. Studies with RU 486 (mifepristone).

Authors:  B Leighton; M Parry-Billings; G Dimitriadis; J Bond; E A Newsholme; C DaCosta; E A Foot
Journal:  Biochem J       Date:  1991-02-15       Impact factor: 3.857

9.  Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle.

Authors:  G Girard; R F Butterworth
Journal:  Dig Dis Sci       Date:  1992-07       Impact factor: 3.199

10.  A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells.

Authors:  J C Street; A M Delort; P S Braddock; K M Brindle
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

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