| Literature DB >> 2049080 |
M Parry-Billings1, S J Bevan, E Opara, E A Newsholme.
Abstract
The effect of changes in cell volume on the rates of release of glutamine and alanine from muscle and on the concentrations of these amino acids in muscle were investigated by using an isolated preparation of rat skeletal muscle incubated in the presence of hypo- and hyper-osmotic media. Changes in cell volume were associated with changes in the rates of release of glutamine and alanine from muscle: incubation in hypo-osmotic medium decreased the rates of release of glutamine and alanine, and incubation in hyperosmotic medium increased these rates. These changes were rapidly reversed by a change in osmoticity of the medium. Despite marked changes in cell volume, the concentrations of these amino acids in muscle were maintained. It is suggested that cell volume may play a role in the regulation of amino acid metabolism in skeletal muscle.Entities:
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Year: 1991 PMID： 2049080 PMCID： PMC1151128 DOI： 10.1042/bj2760559
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857