Literature DB >> 6140301

Effects of retinal and pineal low molecular weight fractions and antipsychotic drugs on hydroxyindole-O-methyltransferase.

G Cremer-Bartels, I Ebels, J E Sykes, A de Morée.   

Abstract

Fractions from bovine retinas and sheep pineals of low molecular weight decrease the activity of purified hydroxyindole-O-methyltransferase (HIOMT). The antipsychotic drugs chlorpromazine and haloperidol show a similar effect under the same experimental conditions. It is suggested that they may imitate the effect of (an) unknown natural suppressor(s) of HIOMT-activity, present in retina and pineal, decreasing the biosynthesis of methoxyindoles.

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Year:  1983        PMID： 6140301     DOI： 10.1007/bf01249129

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  12 in total

1.  Separation of pineal extracts by gelfiltration. VI. Isolation and identification from sheep pineals of biopterin; comparison of the isolated compound with some synthetic pteridines and the biological activity in in vitro and in vivo bioassays.

Authors:  M L van der Have-Kirchberg; A de Morée; J F van Laar; G J Gerwig; C Versluis; I Ebels
Journal:  J Neural Transm       Date:  1977       Impact factor: 3.575

2.  Localization of a sheep pineal antigonadotropin.

Authors:  I Ebels; B Benson; M J Matthews
Journal:  Anal Biochem       Date:  1973-12       Impact factor: 3.365

3.  The distribution of haloperidol in rat brain.

Authors:  R J Naylor; J E Olley
Journal:  Br J Pharmacol       Date:  1969-05       Impact factor: 8.739

4.  [Effect of chlorpromazine on biosynthesis of melatonin in the retina].

Authors:  G Cremer-Bartels; F Kaufmann; H J Küchle
Journal:  Fortschr Ophthalmol       Date:  1983

5.  Separation of pineal extracts by gelfiltration. IV. Isolation, location and identification from sheep pineals of three indoles, identical with 5-hydroxytryptophol, 5-methoxytryptophol and melatonin.

Authors:  I Ebels; A E Horwitz-Bresser
Journal:  J Neural Transm       Date:  1976       Impact factor: 3.575

6.  Separation of pineal extracts by gelfiltration. II. Identification and isolation of two indoles from sheep pineal glands.

Authors:  W Zurburg; I Ebels
Journal:  J Neural Transm       Date:  1975       Impact factor: 3.575

7.  Human post-mortem pineal enzyme activity.

Authors:  J A Smith; T J Mee; D J Padwick; E G Spokes
Journal:  Clin Endocrinol (Oxf)       Date:  1981-01       Impact factor: 3.478

8.  Inhibition of avian and mammalian hydroxy-indole-o-methyl-transferase (HIOMT) with low molecular weight fractions of mammalian pineal glands.

Authors:  I Ebels; G Cremer-Bartels
Journal:  Life Sci       Date:  1982-04-19       Impact factor: 5.037

9.  Pteridines as nonretinal regulators of light-dependent melatonin biosynthesis.

Authors:  G Cremer-Bartels; I Ebels
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

10.  MELATONIN SYNTHESIS IN THE PINEAL GLAND: CONTROL BY LIGHT.

Authors:  R J WURTMAN; J AXELROD; L S PHILLIPS
Journal:  Science       Date:  1963-11-22       Impact factor: 47.728
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  1 in total

1.  Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5.

Authors:  Shaohui Wang; Lingqiang Zhu; Hairong Shi; Hongyun Zheng; Qing Tian; Qun Wang; Rong Liu; Jian-Zhi Wang
Journal:  Neurochem Res       Date:  2007-03-31       Impact factor: 3.996
  1 in total

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