Literature DB >> 14068225

MELATONIN SYNTHESIS IN THE PINEAL GLAND: CONTROL BY LIGHT.

R J WURTMAN, J AXELROD, L S PHILLIPS.   

Abstract

In rats placed in continuous darkness for 6 days, there is a striking increase in the activity of melatonin-synthesizing-enzyme (hydroxyindole-0-methyl transferase) in the pineal gland, but no change in the activity of monoamine oxidase. Since melatonin appears to have a hormonal role in mammals, and its synthesis is confined to the pineal gland, the inhibition of hydroxyindole-O-methyl transferase by light may constitute a mechanism of neuroendocrine regulation.

Entities:  

Keywords:  EXPERIMENTAL LAB STUDY; INDOLES; LIGHT; METABOLISM; PINEAL BODY; RATS; TRANSFERASES

Mesh：

Substances：

Year:  1963        PMID： 14068225     DOI： 10.1126/science.142.3595.1071

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  64 in total

1.  The effect of luteineizing hormone on chicken testis and pineal gland uptake of 32P.

Authors:  J W Sackman
Journal:  Experientia       Date:  1975-11-15

2.  Melatonin excretion of man and rats: effect of time of day, sleep, pinealectomy and food consumption.

Authors:  H J Lynch; Y Ozaki; D Shakal; R J Wurtman
Journal:  Int J Biometeorol       Date:  1975-12       Impact factor: 3.787

3.  The effect of heat on rat pineal hydroxyindole-omichron-methyl transferase activity.

Authors:  I Nir; N Hirschmann; F G Sulman
Journal:  Experientia       Date:  1975-07-15

4.  History of the development of sleep medicine in the United States.

Authors:  John W Shepard; Daniel J Buysse; Andrew L Chesson; William C Dement; Rochelle Goldberg; Christian Guilleminault; Cameron D Harris; Conrad Iber; Emmanuel Mignot; Merrill M Mitler; Kent E Moore; Barbara A Phillips; Stuart F Quan; Richard S Rosenberg; Thomas Roth; Helmut S Schmidt; Michael H Silber; James K Walsh; David P White
Journal:  J Clin Sleep Med       Date:  2005-01-15       Impact factor: 4.062

5.  Seasonal pattern of melatonin excretion in humans: relationship to daylength variation rate and geomagnetic field fluctuations.

Authors:  T J Paparrigopoulos; C N Stefanis
Journal:  Experientia       Date:  1996-03-15

6.  Control of the rat pineal gland by light spectra.

Authors:  D P Cardinali; F Larin; R J Wurtman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

7.  Effect of melatonin on induction of ovulation in the light- induced constant estrous-anovulatory syndrome and possible role of the brain serotoninergic system.

Authors:  G P Trentini; B Mess; C F De Gaetani; C Ruzsás
Journal:  J Endocrinol Invest       Date:  1978-10       Impact factor: 4.256

8.  Circadian rhythms of pineal N-acetyltransferase activity in the Djungarian hamster, Phodopus sungorus, in response to seasonal changes of natural photoperiod.

Authors:  S Steinlechner; A Buchberger; G Heldmaier
Journal:  J Comp Physiol A       Date:  1987-05       Impact factor: 1.836

Review 9.  The adrenal medulla may mediate the increase in pineal melatonin synthesis induced by stress, but not that caused by exposure to darkness.

Authors:  H J Lynch; M Ho; R J Wurtman
Journal:  J Neural Transm       Date:  1977       Impact factor: 3.575

10.  Effects of retinal and pineal low molecular weight fractions and antipsychotic drugs on hydroxyindole-O-methyltransferase.

Authors:  G Cremer-Bartels; I Ebels; J E Sykes; A de Morée
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575
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