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Literature DB >> 6930641

Pteridines as nonretinal regulators of light-dependent melatonin biosynthesis.

Abstract

6-Formylpterin was purified by paper chromatography, and bovine pineal hydroxyindole-O-methyltransferase (S-adenosyl-L-methionine:N-acetylserotonin O-methyl-transferase; EC 2.1.1.4) was purified by flat-bed gel electrofocusing. Fractions of the methyltransferase with isoelectric points at pH 5.0, 5.7, and 5.2 were tested in the presence of 6-formylpterin, and decreased activities were found. Because 6-formylpterin is one of the photolytic products of folic acid and decreased serum folic acid has been reported in light-exposed men, we suggest that pteridines may be involved in nonretinal effects of light on pineal melatonin biosynthesis. It may be that this metabolic pathway is an evolutionary relic of primitive light responses of pigmentation mechanism.

Entities: Chemical Gene Species

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Year: 1980 PMID： 6930641 PMCID： PMC349409 DOI： 10.1073/pnas.77.5.2415

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Purification and properties of hydroxyindole-O-methyl transferase.

Authors: J AXELROD; H WEISSBACH
Journal: J Biol Chem Date: 1961-01 Impact factor: 5.157

2. Separation of pineal extracts by gelfiltration. VI. Isolation and identification from sheep pineals of biopterin; comparison of the isolated compound with some synthetic pteridines and the biological activity in in vitro and in vivo bioassays.

Authors: M L van der Have-Kirchberg; A de Morée; J F van Laar; G J Gerwig; C Versluis; I Ebels
Journal: J Neural Transm Date: 1977 Impact factor: 3.575

3. A chemical study of some biologically active pineal fractions.

Authors: I Ebels
Journal: Prog Brain Res Date: 1979 Impact factor: 2.453

4. Physiological effects of melatonin. Chairman's introduction.

Authors: R J Wurtman
Journal: J Neural Transm Suppl Date: 1978

5. Isolation and characterization of multiple forms of hydroxyindole-O-methyltransferase.

Authors: R L Jackson; W Lovenberg
Journal: J Biol Chem Date: 1971-07-10 Impact factor: 5.157

6. [Melatonin biosynthesis in the mammalian retina in dependence of light adaptation (author's transl)].

Authors: G Cremer-Bartels; F Hollwich; W Kotulla
Journal: Klin Monbl Augenheilkd Date: 1975-07 Impact factor: 0.700

7. The effect of pteridines on multiple forms of hydroxyindole-O-methyltransferase (HIOMT) in the retina and the pineal gland.

Authors: G Cremer-Bartels
Journal: Prog Brain Res Date: 1979 Impact factor: 2.453

8. Skin color and nutrient photolysis: an evolutionary hypothesis.

Authors: R F Branda; J W Eaton
Journal: Science Date: 1978-08-18 Impact factor: 47.728

9. A survey of some active sheep pineal fractions and a discussion on the possible significance of pteridines in those fractions in in vitro and in vivo assays.

Authors: I Ebels; A de Morée; A Hus-Citharel; A Moszkowska
Journal: J Neural Transm Date: 1979 Impact factor: 3.575

10. Melatonin synthesis by the retina.

Authors: W A Gern; C L Ralph
Journal: Science Date: 1979-04-13 Impact factor: 47.728

6 in total

Review 1. Neurobiological aspects of extraretinal photoreceptive systems: structure and function.

Authors: H G Hartwig; A Oksche
Journal: Experientia Date: 1982-09-15

Review 2. [Pterins: pigments, cofactors and signal connections in cell interactions].

Authors: I Ziegler
Journal: Naturwissenschaften Date: 1987-12

3. Effects of retinal and pineal low molecular weight fractions and antipsychotic drugs on hydroxyindole-O-methyltransferase.

Authors: G Cremer-Bartels; I Ebels; J E Sykes; A de Morée
Journal: J Neural Transm Date: 1983 Impact factor: 3.575