Literature DB >> 6138716

Partial agonist effect of 2-[2-(1,4-benzodioxanyl)]-2-imidazoline (RX 781 094) at presynaptic alpha 2-adrenoceptors in rabbit ear artery.

N limberger, K Starke.   

Abstract

Ear arteries from rabbits were preincubated with 3H-noradrenaline and then perfused. 2-[2-(1,4-Benzodioxanyl)]-2-imidazoline (RX 781094) 0.1 or 1 microM reduced the overflow of 3H-noradrenaline and total tritium elicited by 13 electrical pulses at 0.25 Hz or 26 Pulses at 0.5 Hz. RX 781 094 1 microM increased the overflow elicited by 52 pulses at 1 Hz. The inhibitory effects were blocked by yohimbine 10 microM but not by prazosin 1 microM. The alleged antagonist RX 781 094 possesses intrinsic activity at the presynaptic alpha 2-autoreceptors of the ear artery.

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Year:  1983        PMID： 6138716     DOI： 10.1007/bf00647842

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  13 in total

1.  Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit.

Authors:  R Weitzell; T Tanaka; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-08       Impact factor: 3.000

2.  Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine.

Authors:  K Starke; E Borowski; T Endo
Journal:  Eur J Pharmacol       Date:  1975-12       Impact factor: 4.432

3.  Preferential metabolism of (-) 3 H-norepinephrine through the deaminated glycol in the rat vas deferens.

Authors:  K H Graffe; F J Stefano; S Z Langer
Journal:  Biochem Pharmacol       Date:  1973-05-15       Impact factor: 5.858

4.  In vitro studies with (imidazolinyl-2)-2-benzodioxane-1-4 ((+/-)-170 150), a new potent alpha 2-adrenoceptor blocking agent.

Authors:  H Dabiré; J P Dausse; P Mouillé; H Schmitt; P Meyer
Journal:  Eur J Pharmacol       Date:  1982-12-17       Impact factor: 4.432

5.  Alpha-adrenergic receptors in liver membranes: delineation with subtype selective radioligands.

Authors:  B B Hoffman; D F Dukes; R J Lefkowitz
Journal:  Life Sci       Date:  1981-01-19       Impact factor: 5.037

6.  Presynaptic activity of the imidazolidine derivative ST 587, a highly selective alpha 1-adrenoceptor agonist.

Authors:  W Kobinger; L Pichler
Journal:  Eur J Pharmacol       Date:  1982-08-27       Impact factor: 4.432

7.  Characterization of alpha-adrenergic receptor subtypes in the rat renal cortex. Differential regulation of alpha 1- and alpha 2-adrenergic receptors by guanyl nucleotides and Na.

Authors:  M D Snavely; P A Insel
Journal:  Mol Pharmacol       Date:  1982-11       Impact factor: 4.436

8.  Studies on RX 781094: a selective, potent and specific antagonist of alpha 2-adrenoceptors.

Authors:  J C Doxey; A G Roach; C F Smith
Journal:  Br J Pharmacol       Date:  1983-03       Impact factor: 8.739

9.  Characteristics of the [3H]-yohimbine binding on rat brain alpha2-adrenoceptors.

Authors:  B Rouot; M C Quennedey; J Schwartz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-12       Impact factor: 3.000

10.  Functional characterization of central alpha-adrenoceptors by yohimbine diastereomers.

Authors:  L Hedler; G Stamm; R Weitzell; K Starke
Journal:  Eur J Pharmacol       Date:  1981-03-05       Impact factor: 4.432
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  22 in total

1.  Presynaptic dopamine DA2-receptors in rabbit jejunal arteries. An electrophysiological study.

Authors:  W Nörenberg; P Illes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-08       Impact factor: 3.000

2.  The effects of idazoxan and other alpha 2-adrenoceptor antagonists on food and water intake in the rat.

Authors:  H C Jackson; I J Griffin; D J Nutt
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

3.  Contraction-mediating alpha 2-adrenoceptors in the mouse vas deferens.

Authors:  R Bültmann; I von Kügelgen; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-06       Impact factor: 3.000

4.  Estimation of pA2 values at presynaptic alpha 2-autoreceptors in rabbit and rat brain cortex in the absence of autoinhibition.

Authors:  N Limberger; A Mayer; G Zier; B Valenta; K Starke; E A Singer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

5.  A difference in the affinity of some selective alpha 2-adrenoceptor antagonists when compared on isolated vasa deferentia of rat and rabbit.

Authors:  N Lattimer; K F Rhodes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-05       Impact factor: 3.000

6.  Species-selective binding of [3H]-idazoxan to alpha 2-adrenoceptors and non-adrenoceptor, imidazoline binding sites in the central nervous system.

Authors:  J F Hussain; D A Kendall; V G Wilson
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

7.  The effects of idazoxan and other alpha 2-adrenoceptor antagonists on urine output in the rat.

Authors:  H C Jackson; I J Griffin; S D Birkett; D J Nutt
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

8.  In vivo electrophysiological evidence for tonic activation by endogenous noradrenaline of alpha 2-adrenoceptors on 5-hydroxytryptamine terminals in the rat hippocampus.

Authors:  R Mongeau; P Blier; C de Montigny
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-03       Impact factor: 3.000

9.  Further study of prerequisites for the enhancement by alpha-adrenoceptor antagonists of the release of noradrenaline.

Authors:  N Limberger; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-03       Impact factor: 3.000

10.  Methoxamine inhibits noradrenaline release through activation of alpha 1- and alpha 2-adrenoceptors in rat isolated kidney: involvement of purines and prostaglandins.

Authors:  C Bohmann; P Schollmeyer; L C Rump
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-03       Impact factor: 3.000
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