Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A difference in the affinity of some selective alpha 2-adrenoceptor antagonists when compared on isolated vasa deferentia of rat and rabbit.

Literature DB >> 2862589

A difference in the affinity of some selective alpha 2-adrenoceptor antagonists when compared on isolated vasa deferentia of rat and rabbit.

Abstract

The alpha 2-adrenoceptor antagonist potencies of the benzoquinolizines (Wy 26 703, Wy 25 309, Wy 26 392), the benzodioxans (RX 781 094, RS 21 361), yohimbine and rauwolscine have been compared at presynaptic alpha 2-adrenoceptors in the isolated vasa deferentia of the rat and rabbit. Yohimbine and rauwolscine are of equal potency as antagonists in both the rat and rabbit against the agonists clonidine or UK 14304. The benzoquinolizines and benzodioxans are very weak antagonists of clonidine or UK 14304 at the presynaptic alpha 2-adrenoceptors of the rabbit vas deferens when compared to their potency at the presynaptic alpha 2-adrenoceptors of the rat vas deferens. This suggests that the presynaptic alpha 2-adrenoceptors present in the rat vasa deferentia may be different from those present in the rabbit vasa deferentia.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1985 PMID： 2862589 DOI： 10.1007/bf00501880

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

18 in total

1. Pre- and postsynaptic alpha-adrenoceptor antagonism by indoramin in isolated tissues of the rat.

Authors: K F Rhodes; J F Waterfall
Journal: J Pharm Pharmacol Date: 1978-08 Impact factor: 3.765

2. Studies on neurotransmission mechanisms in the rat and guinea-pig vas deferens.

Authors: G Swedin
Journal: Acta Physiol Scand Suppl Date: 1971

Review 3. Alpha-adrenoceptor subclassification.

Authors: K Starke
Journal: Rev Physiol Biochem Pharmacol Date: 1981 Impact factor: 5.545

4. Effect of duration and frequency of stimulation on the presynaptic inhibition by alpha-adrenoceptor stimulation of the adrenergic transmission.

Authors: E S Vizi; G T Somogyi; P Hadházy; J Knoll
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

5. An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferens.

Authors: P G Anton; M E Duncan; J C McGrath
Journal: J Physiol Date: 1977-12 Impact factor: 5.182

6. alpha-Adrenoceptor-mediated inhibition of noradrenaline release in rabbit brain cortex slices. Receptor properties and role of the biophase concentration of noradrenaline.

Authors: D Reichenbacher; W Reimann; K Starke
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1982-04 Impact factor: 3.000

7. Some quantitative uses of drug antagonists.

Authors: O ARUNLAKSHANA; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1959-03

8. Partial agonist effect of 2-[2-(1,4-benzodioxanyl)]-2-imidazoline (RX 781 094) at presynaptic alpha 2-adrenoceptors in rabbit ear artery.

Authors: N limberger; K Starke
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1983-09 Impact factor: 3.000

9. Studies on RX 781094: a selective, potent and specific antagonist of alpha 2-adrenoceptors.

Authors: J C Doxey; A G Roach; C F Smith
Journal: Br J Pharmacol Date: 1983-03 Impact factor: 8.739

10. Alpha 2-adrenoceptor antagonism and other pharmacological antagonist properties of some substituted benzoquinolizines and yohimbine in vitro.

Authors: N Lattimer; R P McAdams; K F Rhodes; S Sharma; S J Turner; J F Waterfall
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1984-10 Impact factor: 3.000

14 in total

1. Estimation of the biophase concentration of noradrenaline at presynaptic alpha 2-adrenoceptors in brain slices.

Authors: C Allgaier; E Agneter; T J Feuerstein; E A Singer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1992-04 Impact factor: 3.000

2. Pharmacological characterization of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery.

Authors: G J Molderings; F Hentrich; M Göthert
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1991-12 Impact factor: 3.000

3. Pharmacological analysis of postjunctional alpha-adrenoceptors mediating contractions to (-)-noradrenaline in the rabbit isolated lateral saphenous vein can be explained by interacting responses to simultaneous activation of alpha 1- and alpha 2-adrenoceptors.

Authors: C J Daly; J C McGrath; V G Wilson
Journal: Br J Pharmacol Date: 1988-10 Impact factor: 8.739

4. Subclassification of presynaptic alpha 2-adrenoceptors: alpha 2A-autoreceptors in rabbit atria and kidney.

Authors: N Limberger; L Funk; A U Trendelenburg; K Starke
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1995-07 Impact factor: 3.000

5. Subclassification of the presynaptic alpha 2-autoreceptors in rabbit brain cortex.

Authors: N Limberger; L Späth; K Starke
Journal: Br J Pharmacol Date: 1991-05 Impact factor: 8.739

6. Estimation of pA2 values at presynaptic alpha 2-autoreceptors in rabbit and rat brain cortex in the absence of autoinhibition.

Authors: N Limberger; A Mayer; G Zier; B Valenta; K Starke; E A Singer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1989-12 Impact factor: 3.000

10. Some pharmacological properties of Wy 27127 a more selective alpha 2:alpha 1-adrenoceptor antagonist than idazoxan in vitro.

Authors: S J Bill; A Boniface; F Haroun; R P McAdams; N Lattimer; K F Rhodes
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1986-12 Impact factor: 3.000