Literature DB >> 186273

Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine.

K Starke, E Borowski, T Endo.   

Abstract

Strips of the rabbit main pulmonary artery were preincubated with 3H-noradrenaline. 3 X 10(-8) -- 10(6) M yohimbine enhanced the overflow of tritium and the smooth muscle contraction induced by transmural sympathetic nerve stimulation. The increase of the stimulation-evoked overflow of tritium was prevented by a high concentration of oxymetazoline. The results indicate that yohimbine is more potent in blocking the presynaptic than the postsynaptic alpha-adrenoceptors of the artery.

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Year:  1975        PMID： 186273     DOI： 10.1016/0014-2999(75)90268-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  117 in total

1.  Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors.

Authors:  J C Doxey; C F Smith; J M Walker
Journal:  Br J Pharmacol       Date:  1977-05       Impact factor: 8.739

2.  The non-adrenergic, non-cholinergic response counteracts changes in guinea-pig airway tone with and without sympathetic activation.

Authors:  A Lindén; A Ullman; B E Skoogh; C G Löfdahl
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

3.  Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit.

Authors:  R Weitzell; T Tanaka; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-08       Impact factor: 3.000

4.  Involvement of presynaptic alpha-adrenoceptors in the cardiovascular and sedative effects of FLA-136.

Authors:  P B Timmermans; E Lam; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-03       Impact factor: 3.000

5.  Hyperpolarizing 'alpha 2'-adrenoceptors in rat sympathetic ganglia.

Authors:  D A Brown; M P Caulfield
Journal:  Br J Pharmacol       Date:  1979-03       Impact factor: 8.739

6.  Studies with alpha 2-adrenoceptor agonists and alcohol abstinence syndrome in rats.

Authors:  M P Parale; S K Kulkarni
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

7.  Evidence for a central postsynaptic action of clonidine.

Authors:  M C Koss; H D Christensen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000

8.  Food intake and rumen motility in dwarf goats. Effects of atipamezole on the inhibitory effects induced by detomidine, medetomidine and romifidine.

Authors:  A S van Miert; S M Faghihi; C T van Duin
Journal:  Vet Res Commun       Date:  1994       Impact factor: 2.459

9.  Evidence against the unitary hypothesis of agonist and antagonist action at presynaptic adrenoceptors.

Authors:  S Kalsner
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

10.  Inhibitory alpha 2-adrenergic mechanism regulating gastric secretion in pylorus-ligated rats.

Authors:  T Nakadate; T Nakaki; T Muraki; R Kato
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-08       Impact factor: 3.000
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