Literature DB >> 6134642

Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc- variants are prevented by islet-activating protein.

K Aktories, G Schultz, K H Jakobs.   

Abstract

cyc--Variants of S49 lymphoma cells are defective in the stimulatory guanine nucleotide site of the adenylate cyclase but contain an inhibitory site. Treatment of cyc- cells with islet-activating protein (IAP), which causes ADP-ribosylation of an Mr 40 000 polypeptide in cyc- membranes, abolishes adenylate cyclase inhibition by GTP and the peptide hormone, somatostatin, but not that induced by GTP gamma S. Furthermore, somatostatin-induced stimulation of GTP hydrolysis is lost. Thus, the data indicate that IAP interferes with the adenylate cyclase system by an action at the inhibitory guanine nucleotide site.

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Year:  1983        PMID： 6134642     DOI： 10.1016/0014-5793(83)80701-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Multiple pertussis toxin substrates as candidates for regulatory G proteins of adenylate cyclase coupled to the somatostatin receptor in primary rat astrocytes.

Authors:  P J Gebicke-Haerter; A Seregi; S Wurster; A Schobert; C Allgaier; G Hertting
Journal:  Neurochem Res       Date:  1988-10       Impact factor: 3.996

2.  Somatostatin receptors and the effect of somatostatin on histamine-stimulated adenylate cyclase activity in isolated gastric glands of guinea pigs.

Authors:  K Yoshida; S Nishihara; T Misawa; H Nawata
Journal:  Gastroenterol Jpn       Date:  1989-12

Review 3.  cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs.

Authors:  Klaus Aktories; Peter Gierschik; Dagmar Meyer Zu Heringdorf; Martina Schmidt; Günter Schultz; Thomas Wieland
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-05-17       Impact factor: 3.000

4.  Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains.

Authors:  K A Sullivan; Y C Liao; A Alborzi; B Beiderman; F H Chang; S B Masters; A D Levinson; H R Bourne
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

5.  Islet-activating protein (pertussis toxin) diminishes alpha 2-adrenoceptor mediated effects on noradrenaline release.

Authors:  C Allgaier; T J Feuerstein; R Jackisch; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

6.  Somatostatin potentiates the alpha 1-adrenergic activation of phospholipase C in striatal astrocytes through a mechanism involving arachidonic acid and glutamate.

Authors:  P Marin; J C Delumeau; M Tence; J Cordier; J Glowinski; J Premont
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

7.  The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells.

Authors:  R J Wojcikiewicz; P R Dobson; L I Irons; A Robinson; B L Brown
Journal:  Biochem J       Date:  1984-11-15       Impact factor: 3.857

8.  Heparin uncouples alpha 2-adrenoceptors from the Gi-protein in membranes of human platelets.

Authors:  B Willuweit; K Aktories
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857

9.  Electrogenic bicarbonate secretion in gallbladder: induction by barium via neuronal, possibly VIP-ergic pathways.

Authors:  K U Petersen; R Goergen; F Höfken; H J Macherey; G Sprakties
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-11       Impact factor: 3.000

10.  Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.

Authors:  W Rosenthal; J Hescheler; K D Hinsch; K Spicher; W Trautwein; G Schultz
Journal:  EMBO J       Date:  1988-06       Impact factor: 11.598
  10 in total

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