| Literature DB >> 31101932 |
Klaus Aktories1, Peter Gierschik2, Dagmar Meyer Zu Heringdorf3, Martina Schmidt4, Günter Schultz5, Thomas Wieland6.
Abstract
Karl H. Jakobs, former editor-in-chief of Naunyn-Schmiedeberg's Archives of Pharmacology and renowned molecular pharmacologist, passed away in April 2018. In this article, his scientific achievements regarding G protein-mediated signal transduction and regulation of canonical pathways are summarized. Particularly, the discovery of inhibitory G proteins for adenylyl cyclase, methods for the analysis of receptor-G protein interactions, GTP supply by nucleoside diphosphate kinases, mechanisms in phospholipase C and phospholipase D activity regulation, as well as the development of the concept of sphingosine-1-phosphate as extra- and intracellular messenger will presented. His seminal scientific and methodological contributions are put in a general and timely perspective to display and honor his outstanding input to the current knowledge in molecular pharmacology.Entities:
Keywords: Adenylyl cyclase; Calcium-dependent signaling; Heterotrimeric G protein; Low molecular mass GTP binding protein; Phospholipase C; Phospholipase D; Sphingosine-1-phoshate
Year: 2019 PMID： 31101932 DOI： 10.1007/s00210-019-01650-1
Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000