Literature DB >> 3003591

Islet-activating protein (pertussis toxin) diminishes alpha 2-adrenoceptor mediated effects on noradrenaline release.

C Allgaier, T J Feuerstein, R Jackisch, G Hertting.   

Abstract

The effect of islet-activating protein (IAP) on alpha 2-adrenoceptor mediated modulation of noradrenaline release in the rabbit hippocampus was studied. Slices of the hippocampus were incubated for 6 h with IAP, subsequently loaded with 3H-noradrenaline and superfused continuously. IAP-pretreatment significantly enhanced the electrically evoked transmitter release and diminished the facilitatory effect of the alpha 2-adrenoceptor antagonist yohimbine. In addition, the inhibitory effect of the alpha 2-adrenoceptor agonist clonidine was reduced. These results provide circumstantial evidence that an inhibitory guanine-nucleotide-binding protein, most probably Ni of a presynaptically located adenylate cyclase, is involved in the alpha 2-autoreceptor mediated modulation of noradrenaline release.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3003591     DOI： 10.1007/bf00634243

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  38 in total

Review 1.  Bimodal regulation of adenylate cyclase.

Authors:  D M Cooper
Journal:  FEBS Lett       Date:  1982-02-22       Impact factor: 4.124

2.  Direct action of pertussis toxin in isolated hamster fat cells.

Authors:  M A Martínez-Olmedo; J A García-Sáinz
Journal:  Eur J Pharmacol       Date:  1984-03-16       Impact factor: 4.432

3.  Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase.

Authors:  R D Sekura; F Fish; C R Manclark; B Meade; Y L Zhang
Journal:  J Biol Chem       Date:  1983-12-10       Impact factor: 5.157

4.  Decrease of clonidine binding affinity to alpha 2-adrenoceptor by ADP-ribosylation of 41,000-dalton proteins in rat cerebral cortical membranes by islet-activating protein.

Authors:  Y Nomura; Y Kitamura; T Segawa
Journal:  J Neurochem       Date:  1985-02       Impact factor: 5.372

5.  Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

Authors:  P C Sternweis; J D Robishaw
Journal:  J Biol Chem       Date:  1984-11-25       Impact factor: 5.157

6.  Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

Authors:  T Murayama; M Ui
Journal:  J Biol Chem       Date:  1983-03-10       Impact factor: 5.157

7.  Pharmacological characterizations of adrenergic receptors in human adipocytes.

Authors:  T W Burns; P E Langley; B E Terry; D B Bylund; B B Hoffman; M D Tharp; R J Lefkowitz; J A García-Saínz; J N Fain
Journal:  J Clin Invest       Date:  1981-02       Impact factor: 14.808

8.  Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.

Authors:  K Aktories; G Schultz; K H Jakobs
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-11       Impact factor: 3.000

9.  3H-noradrenaline release from rat neocortical slices in the absence of extracellular Ca2+ and its presynaptic alpha 2-adrenergic modulation. A study on the possible role of cyclic AMP.

Authors:  A N Schoffelmeer; A H Mulder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-07       Impact factor: 3.000

10.  Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

Authors:  H Kurose; T Katada; T Amano; M Ui
Journal:  J Biol Chem       Date:  1983-04-25       Impact factor: 5.157
View more
  24 in total

1.  The effects of ageing on prejunctional 5-hydroxytryptamine receptors in the rat vas deferens.

Authors:  M Borton; J R Docherty
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-08       Impact factor: 3.000

2.  Pertussis toxin abolishes the inhibition of Ca2+ currents and of noradrenaline release via alpha 2-adrenoceptors in chick sympathetic neurons.

Authors:  S Boehm; S Huck; H Drobny; E A Singer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-05       Impact factor: 3.000

3.  Protein kinase C activation and alpha 2-autoreceptor-modulated release of noradrenaline.

Authors:  C Allgaier; G Hertting; H Y Huang; R Jackisch
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

4.  Mutual interaction between presynaptic alpha 2-adrenoceptors and 5-HT1B receptors on the sympathetic nerve terminals of the rat inferior vena cava.

Authors:  G J Molderings; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-05       Impact factor: 3.000

5.  One hundred years of adrenaline: the discovery of autoreceptors.

Authors:  M R Bennett
Journal:  Clin Auton Res       Date:  1999-06       Impact factor: 4.435

6.  No effect of pertussis toxin on peripheral prejunctional alpha 2-adrenoceptor-mediated responses and on endothelium-dependent relaxations in the rat.

Authors:  J R Docherty
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

7.  Pertussis toxin-sensitive GTP-binding proteins characterized in synaptosomal fractions of embryonic avian cerebral cortex.

Authors:  G G Holz; T J Turner
Journal:  Comp Biochem Physiol B Biochem Mol Biol       Date:  1998-01       Impact factor: 2.231

8.  Involvement of pertussis toxin-sensitive and -insensitive mechanisms in alpha-adrenoceptor modulation of noradrenaline release from rat sympathetic neurones in tissue culture.

Authors:  C E Hill; D A Powis; I A Hendry
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

9.  Presynaptic opioid receptors on dopaminergic nerves in the rabbit caudate nucleus: coupling to pertussis toxin-sensitive G-proteins and interaction with D2 autoreceptors?

Authors:  R Jackisch; H Hotz; C Allgaier; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-03       Impact factor: 3.000

10.  Prejunctional alpha 2-adrenoceptors in mouse atria function through G-proteins which are sensitive to N-ethylmaleimide, but not pertussis toxin.

Authors:  T V Murphy; S Foucart; H Majewski
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.