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Literature DB >> 6122102

DNA insertion sequences near the insulin gene affect glucose regulation.

D Owerbach, S Poulsen, P Billesbølle, J Nerup.

Abstract

There is restriction-fragment length polymorphism in the 5'-flanking region of the insulin gene on the short arm of chromosome 11 in man. The polymorphic DNA sequences in 53 members of a large family were analysed by means of the restriction endonuclease BglI. In this family, the BglI restriction fragments were found in four sizes--2.8 kilobases (kb), 2.9 kb, 4.6 kb, and 4.8 kb. They segregated as alleles. The two larger BglI restriction fragments (U alleles) were associated with high haemoglobin Alc levels in both blood-related and unrelated non-diabetic members of the family.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1982 PMID： 6122102 DOI： 10.1016/s0140-6736(82)92152-3

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

10 in total

1. Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth.

Authors: S O'Rahilly; P Patel; O J Lehmann; A Tybjaerg-Hansen; J Nerup; R C Turner; J S Wainscoat
Journal: Hum Genet Date: 1992-05 Impact factor: 4.132

Review 2. Regulatory polymorphisms underlying complex disease traits.

Authors: Julian C Knight
Journal: J Mol Med (Berl) Date: 2004-12-09 Impact factor: 4.599

3. Maturity onset diabetes of the young is not linked to the insulin gene.

Authors: J I Bell; J S Wainscoat; J M Old; C Chlouverakis; H Keen; R C Turner; D J Weatherall
Journal: Br Med J (Clin Res Ed) Date: 1983-02-19

4. DNA insertion sequences near the insulin gene are not associated with maturity-onset diabetes of young people.

Authors: D Owerbach; B Thomsen; K Johansen; L U Lamm; J Nerup
Journal: Diabetologia Date: 1983-07 Impact factor: 10.122

5. Lack of association of the insulin gene region with type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.

Authors: C Matsumoto; T Awata; Y Iwamoto; T Kuzuya; T Saito; Y Kanazawa
Journal: Diabetologia Date: 1994-02 Impact factor: 10.122

10. Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians.

Authors: W C Knowler; D J Pettitt; B Vasquez; P S Rotwein; T L Andreone; M A Permutt
Journal: J Clin Invest Date: 1984-12 Impact factor: 14.808

10 in total

DNA insertion sequences near the insulin gene affect glucose regulation.

1. Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth.

Review 2. Regulatory polymorphisms underlying complex disease traits.

3. Maturity onset diabetes of the young is not linked to the insulin gene.

4. DNA insertion sequences near the insulin gene are not associated with maturity-onset diabetes of young people.

5. Lack of association of the insulin gene region with type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.

Review 6. Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review.

7. Studies on mutant human insulin genes: identification and sequence analysis of a gene encoding [SerB24]insulin.

8. Genetics of diabetes in Nauru: effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism.

9. Diabetes mellitus, atherosclerosis, and the 5' flanking polymorphism of the human insulin gene.

10. Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians.