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Literature DB >> 6118870

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

A Goldstein, W Fischli, L I Lowney, M Hunkapiller, L Hood.

Abstract

The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus--longitudinal muscle bioassay. The potency is accounted for by the first 13 residues.

Entities: Chemical Species

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Year: 1981 PMID： 6118870 PMCID： PMC349228 DOI： 10.1073/pnas.78.11.7219

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties.

Authors: B M Cox; K E Opheim; H Teschemacher; A Goldstein
Journal: Life Sci Date: 1975-06-15 Impact factor: 5.037

2. A pituitary endorphin with novel properties.

Authors: L I Lowney; S B Gentleman; A Goldstein
Journal: Life Sci Date: 1979-06-18 Impact factor: 5.037

3. Dynorphin-(1-13), an extraordinarily potent opioid peptide.

Authors: A Goldstein; S Tachibana; L I Lowney; M Hunkapiller; L Hood
Journal: Proc Natl Acad Sci U S A Date: 1979-12 Impact factor: 11.205

Review 4. In vitro models in the study of structure-activity relationships of narcotic analgesics.

Authors: H W Kosterlitz; A A Waterfield
Journal: Annu Rev Pharmacol Date: 1975 Impact factor: 13.820

5. Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit.

Authors: R B Carlsen; O P Bahl; N Swaminathan
Journal: J Biol Chem Date: 1973-10-10 Impact factor: 5.157

6. Specific receptor for the opioid peptide dynorphin: structure--activity relationships.

Authors: C Chavkin; A Goldstein
Journal: Proc Natl Acad Sci U S A Date: 1981-10 Impact factor: 11.205

7. Immunoreactive dynorphin in pituitary and brain.

Authors: A Goldstein; V E Ghazarossian
Journal: Proc Natl Acad Sci U S A Date: 1980-10 Impact factor: 11.205

8. Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus.

Authors: C Chavkin; A Goldstein
Journal: Nature Date: 1981-06-18 Impact factor: 49.962

9. The amino-acid sequence of leghemoglobin component a from Phaseolus vulgaris (kidney bean).

Authors: P Lehtovaara; N Ellfolk
Journal: Eur J Biochem Date: 1975-06

10. Snake venom toxins. The purification of toxins VII1 and VII2, two cytotoxin homologues from banded Egyptian cobra (Naja haje annulifera) venom, and the complete amino acid sequence of toxin VII1.

Authors: K H Weise; F H Carlsson; F J Joubert; D J Strydom
Journal: Hoppe Seylers Z Physiol Chem Date: 1973 Oct-Nov

59 in total

9. Increased spinal prodynorphin gene expression in reinflammation-associated hyperalgesia after neonatal inflammatory insult.

Authors: Jack Yu-Shih Lin; Yu-Che Cheng; Julia Yi-Ru Chen; Chih-Cheng Chien; Shih-Chang Lin; Yeong-Ray Wen; Tsung-Shan Tsou; Qing-Dong Ling
Journal: BMC Neurosci Date: 2010-10-25 Impact factor: 3.288

Review 10. Dynorphin--still an extraordinarily potent opioid peptide.

Authors: Charles Chavkin
Journal: Mol Pharmacol Date: 2012-11-14 Impact factor: 4.436

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

1. A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties.

2. A pituitary endorphin with novel properties.

3. Dynorphin-(1-13), an extraordinarily potent opioid peptide.

Review 4. In vitro models in the study of structure-activity relationships of narcotic analgesics.

5. Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit.

6. Specific receptor for the opioid peptide dynorphin: structure--activity relationships.

7. Immunoreactive dynorphin in pituitary and brain.

8. Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus.

9. The amino-acid sequence of leghemoglobin component a from Phaseolus vulgaris (kidney bean).

10. Snake venom toxins. The purification of toxins VII1 and VII2, two cytotoxin homologues from banded Egyptian cobra (Naja haje annulifera) venom, and the complete amino acid sequence of toxin VII1.

Review 1. The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.

Review 2. Dynorphin A analogs for the treatment of chronic neuropathic pain.

3. 75 years of opioid research: the exciting but vain quest for the Holy Grail.

Review 4. 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases.

5. "DAKLI": a multipurpose ligand with high affinity and selectivity for dynorphin (kappa opioid) binding sites.

6. Chimeric opioid peptides: tools for identifying opioid receptor types.

7. Striato-nigral dynorphin and substance P pathways in the rat. I. Biochemical and immunohistochemical studies.

8. Neuropeptide Y: complete amino acid sequence of the brain peptide.

9. Increased spinal prodynorphin gene expression in reinflammation-associated hyperalgesia after neonatal inflammatory insult.

Review 10. Dynorphin--still an extraordinarily potent opioid peptide.