Literature DB >> 2902630

"DAKLI": a multipurpose ligand with high affinity and selectivity for dynorphin (kappa opioid) binding sites.

A Goldstein1, J J Nestor, A Naidu, S R Newman.   

Abstract

We describe a synthetic ligand, "DAKLI" (Dynorphin A-analogue Kappa LIgand), related to the opioid peptide dynorphin A. A single reactive amino group at the extended carboxyl terminus permits various reporter groups to be attached, such as 125I-labeled Bolton-Hunter reagent, fluorescein isothiocyanate, or biotin. These derivatives have high affinity and selectivity for the dynorphin (kappa opioid) receptor. An incidental finding is that untreated guinea pig brain membranes have saturable avidin binding sites.

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Year:  1988        PMID： 2902630      PMCID： PMC282189          DOI： 10.1073/pnas.85.19.7375

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  12 in total

1.  Dynorphin-(1-13), an extraordinarily potent opioid peptide.

Authors:  A Goldstein; S Tachibana; L I Lowney; M Hunkapiller; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

2.  Dynorphin is a specific endogenous ligand of the kappa opioid receptor.

Authors:  C Chavkin; I F James; A Goldstein
Journal:  Science       Date:  1982-01-22       Impact factor: 47.728

3.  Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

Authors:  A Goldstein; W Fischli; L I Lowney; M Hunkapiller; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

4.  Specific receptor for the opioid peptide dynorphin: structure--activity relationships.

Authors:  C Chavkin; A Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

5.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors:  Y Cheng; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858

6.  Structural requirements for delta opioid receptor binding.

Authors:  H I Mosberg; J R Omnaas; A Goldstein
Journal:  Mol Pharmacol       Date:  1987-06       Impact factor: 4.436

7.  U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

Authors:  P F Vonvoigtlander; R A Lahti; J H Ludens
Journal:  J Pharmacol Exp Ther       Date:  1983-01       Impact factor: 4.030

8.  Requirement for biotin and the function of biotin in cells in culture.

Authors:  K Dakshinamurti; L Chalifour; R P Bhullar
Journal:  Ann N Y Acad Sci       Date:  1985       Impact factor: 5.691

9.  Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin.

Authors:  I F James; C Chavkin; A Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

10.  Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

Authors:  H I Mosberg; R Hurst; V J Hruby; K Gee; H I Yamamura; J J Galligan; T F Burks
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205
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  5 in total

1.  Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands.

Authors:  G X Xie; A Miyajima; A Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

2.  6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

Authors:  M Eugenio Vázquez; Juan B Blanco; Severo Salvadori; Claudio Trapella; Roberto Argazzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Mariantonella Colucci; Gianfranco Balboni
Journal:  J Med Chem       Date:  2006-06-15       Impact factor: 7.446

3.  Chimeric opioid peptides: tools for identifying opioid receptor types.

Authors:  G X Xie; A Miyajima; T Yokota; K Arai; A Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

4.  Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.

Authors:  U Bickel; T Yoshikawa; E M Landaw; K F Faull; W M Pardridge
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

5.  Identification of kappa opioid receptors in the immune system by indirect immunofluorescence.

Authors:  D M Lawrence; W el-Hamouly; S Archer; J F Leary; J M Bidlack
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-14       Impact factor: 11.205
  5 in total

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