Literature DB >> 22002579

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.

H A Tejeda1, T S Shippenberg, R Henriksson.   

Abstract

The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and pathophysiology of several psychiatric disorders. In the present review, we present evidence indicating a key role for this system in modulating neurotransmission in brain circuits that subserve mood, motivation, and cognitive function. We overview the pharmacology, signaling, post-translational, post-transcriptional, transcriptional, epigenetic and cis regulation of the dynorphin/κ-opioid receptor system, and critically review functional neuroanatomical, neurochemical, and pharmacological evidence, suggesting that alterations in this system may contribute to affective disorders, drug addiction, and schizophrenia. We also overview the dynorphin/κ-opioid receptor system in the genetics of psychiatric disorders and discuss implications of the reviewed material for therapeutics development.

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Year:  2011        PMID： 22002579     DOI： 10.1007/s00018-011-0844-x

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  460 in total

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Authors:  A Mansour; C A Fox; F Meng; H Akil; S J Watson
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Journal:  Eur J Pharmacol       Date:  2005-10-19       Impact factor: 4.432

5.  Dynorphin and stress-related peptides in rat locus coeruleus: contribution of amygdalar efferents.

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6.  Kappa-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells.

Authors:  Angel Y F Kam; Anthony S L Chan; Yung H Wong
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Review 7.  Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models.

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8.  Depletion of serotonin decreases the effects of the kappa-opioid receptor agonist U-69593 on cocaine-stimulated activity.

Authors:  Elena Zakharova; Stephanie L Collins; Maria Aberg; Adarsh Kumar; J B Fernandez; Sari Izenwasser
Journal:  Eur J Pharmacol       Date:  2008-02-29       Impact factor: 4.432

9.  Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.

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10.  Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats.

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  67 in total

1.  κ-Opioid Receptor Modulation of GABAergic Inputs onto Ventrolateral Periaqueductal Gray Dopamine Neurons.

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3.  Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.

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Review 5.  Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol.

Authors:  Rachel I Anderson; Howard C Becker
Journal:  Alcohol Clin Exp Res       Date:  2017-06-05       Impact factor: 3.455

6.  Tolerance and sensitization to chronic escalating dose heroin following extended withdrawal in Fischer rats: possible role of mu-opioid receptors.

Authors:  Katharine M Seip-Cammack; Brian Reed; Yong Zhang; Ann Ho; Mary Jeanne Kreek
Journal:  Psychopharmacology (Berl)       Date:  2012-07-25       Impact factor: 4.530

7.  Prodynorphin gene promoter polymorphism and temporal lobe epilepsy: A meta-analysis.

Authors:  Na Zhang; Tao-Hui Ouyang; Qing Zhou; Hui-Cong Kang; Sui-Qiang Zhu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2015-10-22

8.  Identification of novel functionally selective κ-opioid receptor scaffolds.

Authors:  Kate L White; Alex P Scopton; Marie-Laure Rives; Ruslan V Bikbulatov; Prabhakar R Polepally; Peter J Brown; Terrance Kenakin; Jonathan A Javitch; Jordan K Zjawiony; Bryan L Roth
Journal:  Mol Pharmacol       Date:  2013-10-10       Impact factor: 4.436

9.  Novel Drugs of Abuse: A Snapshot of an Evolving Marketplace.

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10.  Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity.

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Journal:  Neuropsychopharmacology       Date:  2013-02-27       Impact factor: 7.853
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