Literature DB >> 6108902

Inhibitory effect of somatostatin on gastric acid secretion and serum gastrin in dogs with and without duodenogastric reflux.

W E Thomas.   

Abstract

The hypersecretion of gastric acid in response to pentagastrin, caused by duodenal reflux, was tested in dogs. An infusion of 0.25 micrograms/kg/h was found to restore the raised responses seen in the reflux dogs to control levels. Somatostatin was a strong inhibitor of pentagastrin-stimulated acid secretion and of gastrin release, but it was a weak inhibitor of histamine. These studies suggest that somatostatin may have played a part in acid homeostasis.

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Year:  1980        PMID： 6108902      PMCID： PMC1419284          DOI： 10.1136/gut.21.11.996

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  12 in total

1.  Cellular localization of somatostatin.

Authors:  R Elde; T Hökfelt; O Johansson; M Schultzberg; S Efendić; R Luft
Journal:  Metabolism       Date:  1978-09       Impact factor: 8.694

2.  Immunoreactive somatostatin levels in plasma of normal and alloxan diabetic dogs.

Authors:  V Schusdziarra; R E Dobbs; V Harris; R H Unger
Journal:  FEBS Lett       Date:  1977-09-01       Impact factor: 4.124

Review 3.  Somatostatin and the gastrointestinal secretions.

Authors:  S J Konturek
Journal:  Scand J Gastroenterol       Date:  1976       Impact factor: 2.423

4.  Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells.

Authors:  J M Polak; A G Pearse; L Grimelius; S R Bloom
Journal:  Lancet       Date:  1975-05-31       Impact factor: 79.321

5.  Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs.

Authors:  A A Barros D'Sa; S R Bloom; J H Baron
Journal:  Lancet       Date:  1975-04-19       Impact factor: 79.321

6.  Radioimmunoassay of somatostatin.

Authors:  A Arimura; G Lundqvist; J Rothman; R Chang; R Fernandez-Durango; R Elde; D H Coy; A V Schally; C Meyers
Journal:  Metabolism       Date:  1978-09       Impact factor: 8.694

7.  Effect of growth hormone release-inhibiting hormone on gastric secretion, mucosal blood flow, and serum gastrin.

Authors:  S J Konturek; J Tasler; M Cieszkowski; D H Coy; A V Schally
Journal:  Gastroenterology       Date:  1976-05       Impact factor: 22.682

8.  Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.

Authors:  P Brazeau; W Vale; R Burgus; N Ling; M Butcher; J Rivier; R Guillemin
Journal:  Science       Date:  1973-01-05       Impact factor: 47.728

9.  Pancreatic and gastric somatostatin release in response to intragastric and intraduodenal nutrients and HCl in the dog.

Authors:  V Schusdziarra; V Harris; J M Conlon; A Arimura; R Unger
Journal:  J Clin Invest       Date:  1978-09       Impact factor: 14.808

10.  The effect of somatostatin on pentagastrin-stimulated gastric secretion and on plasma gastrin in man.

Authors:  M H Vatn; E Schrumpf; K F Hanssen; J Myren
Journal:  Scand J Gastroenterol       Date:  1977       Impact factor: 2.423
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  6 in total

1.  The functional and morphological effects of duodeno-gastric reflux and their relation to peptic ulceration.

Authors:  W E Thomas
Journal:  Ann R Coll Surg Engl       Date:  1983-03       Impact factor: 1.891

2.  The somatostatin/histaminic pathway balance on gastric secretion could be based on a competitive antagonism.

Authors:  J Vatier; C Poitevin; W Riquet; M T Vitre; A Olivier; P Martin; S Bonfils
Journal:  Agents Actions       Date:  1988-07

3.  Is somatostatin a humoral regulator of the endocrine pancreas and gastric acid secretion in man?

Authors:  F B Loud; J J Holst; E Egense; B Petersen; J Christiansen
Journal:  Gut       Date:  1985-05       Impact factor: 23.059

4.  Suppression of somatostatin release by duodenogastric reflux in dogs.

Authors:  W E Thomas; J Ardill; K D Buchanan
Journal:  Gut       Date:  1984-11       Impact factor: 23.059

5.  Effect of somatostatin, secretin, and glucagon on secretagogue stimulated aminopyrine uptake in isolated canine parietal cells.

Authors:  E Perez-Reyes; N A Payne; J G Gerber
Journal:  Agents Actions       Date:  1983-06

6.  Increased Risk of Peptic Ulcers Following a Cholecystectomy for Gallstones.

Authors:  Ming-Chieh Tsai; Chung-Chien Huang; Li-Ting Kao; Herng-Ching Lin; Cha-Ze Lee
Journal:  Sci Rep       Date:  2016-07-29       Impact factor: 4.379
  6 in total

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