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Literature DB >> 6107221

Effect of ranitidine, a new H2-antagonist, on gastric and pancreatic secretion in duodenal ulcer patients.

S J Konturek, W Obtułowicz, N Kwiecień, E Sito, J Oleksy, B Miszczuk-Jamska.

Abstract

The effects of a new H2-receptor blocker, ranitidine, given intravenously (for comparison with cimetidine) or orally an gastric and pancreatic secretion have been studied in duodenal ulcer patients. Ranitidine appears to be several times more potent and a longer-acting inhibitor of gastric secretion than cimetidine. This H2 blocker does not affect pancreatic bicarbonate and enzyme secretion.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6107221 DOI： 10.1007/bf01345291

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

18 in total

1. A spectrophotometric determination of trypsin and chymotrypsin.

Authors: G W SCHWERT; Y TAKENAKA
Journal: Biochim Biophys Acta Date: 1955-04

2. Cimetidine in the treatment of duodenal ulcer: a multicenter double blind study.

Authors: H J Binder; A Cocco; R J Crossley; W Finkelstein; R Font; G Friedman; J Groarke; W Hughes; A F Johnson; J E McGuigan; R Summers; R Vlahcevic; E C Wilson; D H Winship
Journal: Gastroenterology Date: 1978-02 Impact factor: 22.682

3. Definition and antagonism of histamine H 2 -receptors.

Authors: J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal: Nature Date: 1972-04-21 Impact factor: 49.962

4. Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients.

Authors: S J Konturek; W Obtulowicz; N Kwiecien; E Sito; E Mikos; J Oleksy
Journal: Gut Date: 1980-03 Impact factor: 23.059

5. Gastric inhibitory action of H2-antagonists ranitidine and cimetidine.

Authors: W Domschke; G Lux; S Domschke
Journal: Lancet Date: 1979-02-10 Impact factor: 79.321

6. Gynaecomastia with cimetidine.

Authors: G F Delle Fave; G Tamburrano; L De Magistris; C Natoli; M L Santoro; R Carratu; A Torsoli
Journal: Lancet Date: 1977-06-18 Impact factor: 79.321

7. Bioavailability of cimetidine in man.

Authors: S S Walkenstein; J W Dubb; W C Randolph; W J Westlake; R M Stote; A P Intoccia
Journal: Gastroenterology Date: 1978-02 Impact factor: 22.682

8. Effect of glucagon on meal-induced gastric secretion in man.

Authors: S J Konturek; J Biernat; N Kwiecień; J Oleksy
Journal: Gastroenterology Date: 1975-03 Impact factor: 22.682

9. Postprandial gastric, pancreatic, and biliary response to histamine H2-receptor antagonists active duodenal ulcer.

Authors: G F Longstreth; V L Go; J R Malagelada
Journal: Gastroenterology Date: 1977-01 Impact factor: 22.682

10. THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN.

Authors: M L Anson
Journal: J Gen Physiol Date: 1938-09-20 Impact factor: 4.086

9 in total

1. pH-feedback controlled infusions of ranitidine are no more effective than fixed-dose infusions in reducing gastric acidity and variability in antisecretory responses.

Authors: C H Wilder-Smith; F Halter; W Häcki; H S Merki
Journal: Br J Clin Pharmacol Date: 1992-05 Impact factor: 4.335

Review 2. Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 2. Tests of pancreatic secretion.

Authors: E J Boyd; K G Wormsley
Journal: Int J Pancreatol Date: 1987-08

Review 3. Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases.

Authors: R N Brogden; A A Carmine; R C Heel; T M Speight; G S Avery
Journal: Drugs Date: 1982-10 Impact factor: 9.546