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Literature DB >> 6105116

Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients.

S J Konturek, W Obtulowicz, N Kwiecien, E Sito, E Mikos, J Oleksy.

Abstract

The effects of ranitidine, a new H2-receptor antagonist which does not contain an imidazole ring, and cimetidine have been determined on histamine, meal-induced gastric acid secretion, and serum gastrin levels in duodenal ulcer patients. Compared with cimetidine, ranitidine was found to be about eight times more potent an inhibitor of histamine-induced secretion and four to five times more potent an inhibitor of sham-feeding, and real feeding induced acid secretion without effecting serum gastrin levels.

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Year: 1980 PMID： 6105116 PMCID： PMC1420343 DOI： 10.1136/gut.21.3.181

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

17 in total

1. Effect of metiamide, a histamine H2-receptor antagonist, on gastric response to histamine, pentagastrin, insulin, and peptone meal in man.

Authors: S J Konturek; J Biernat; J Oleksy
Journal: Am J Dig Dis Date: 1974-07

2. Definition and antagonism of histamine H 2 -receptors.

Authors: J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal: Nature Date: 1972-04-21 Impact factor: 49.962

3. Radioimmunoassay of gastrin.

Authors: R S Yalow; S A Berson
Journal: Gastroenterology Date: 1970-01 Impact factor: 22.682

4. Gynaecomastia with cimetidine.

Authors: G F Delle Fave; G Tamburrano; L De Magistris; C Natoli; M L Santoro; R Carratu; A Torsoli
Journal: Lancet Date: 1977-06-18 Impact factor: 79.321

5. Influence of feeding and sham feeding upon serum gastrin and gastric acid secretion in control subjects and duodenal ulcer patients.

Authors: G Mayer; R Arnold; G Feurle; K Fuchs; H Ketterer; N S Track; W Creutzfeldt
Journal: Scand J Gastroenterol Date: 1974-11 Impact factor: 2.423

6. Gastric acid and plasma gastrin responses to sham feeding in duodenal ulcer patients before and after resection of antrum and duodenal bulb.

Authors: U Knutson; L Olbe; P C Ganguli
Journal: Scand J Gastroenterol Date: 1974 Impact factor: 2.423

7. Effect of metiamide, a histamine H2-receptor antagonist, on mucosal blood flow and serum gastrin level.

Authors: S J Konturek; J Tasler; W Obtulowicz; J F Rehfeld
Journal: Gastroenterology Date: 1974-05 Impact factor: 22.682

8. Cimetidine and mental confusion.

Authors: M A McMillen; D Ambis; J H Siegel
Journal: N Engl J Med Date: 1978-02-02 Impact factor: 91.245

9. Effect of glucagon on meal-induced gastric secretion in man.

Authors: S J Konturek; J Biernat; N Kwiecień; J Oleksy
Journal: Gastroenterology Date: 1975-03 Impact factor: 22.682

10. Cimetidine, an H2-antihistamine, stimulates prolactin secretion in man.

Authors: H E Carlson; A F Ippoliti
Journal: J Clin Endocrinol Metab Date: 1977-08 Impact factor: 5.958

26 in total

1. pH-feedback controlled infusions of ranitidine are no more effective than fixed-dose infusions in reducing gastric acidity and variability in antisecretory responses.

Authors: C H Wilder-Smith; F Halter; W Häcki; H S Merki
Journal: Br J Clin Pharmacol Date: 1992-05 Impact factor: 4.335

2. A long lasting gastrin response to apomorphine revealed by inhibitors of gastric acid secretion.

Authors: M Goiny; K Brodin; C E Elwin; K Uvnäs-Moberg
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1987-07 Impact factor: 3.000

3. Effects of eight weeks' continuous treatment with oral ranitidine and cimetidine on gastric acid secretion, pepsin secretion, and fasting serum gastrin.

Authors: R Mohammed; R J Holden; J B Hearns; B M McKibben; K D Buchanan; G P Crean
Journal: Gut Date: 1983-01 Impact factor: 23.059

4. Oxmetidine: clinical pharmacological studies with a new H2-receptor antagonist.

Authors: J G Mills; P L Brunet; R Griffiths; R H Hunt; D Vincent; G J Milton-Thompson; W L Burland
Journal: Gut Date: 1982-02 Impact factor: 23.059

5. Ranitidine upon meal-induced gastric secretion: oral pharmacokinetics and plasma concentration effect relationships.

Authors: M Mignon; N P Chau; B K Nguyen-Phuoc; M Sauvage; F Leguy; S Bonfils
Journal: Br J Clin Pharmacol Date: 1982-08 Impact factor: 4.335

Review 6. Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases.

Authors: R N Brogden; A A Carmine; R C Heel; T M Speight; G S Avery
Journal: Drugs Date: 1982-10 Impact factor: 9.546

7. Comparison of twice-daily ranitidine with standard cimetidine treatment of duodenal ulcer.

Authors: R P Walt; I F Trotman; R Frost; P L Golding; T H Shepherd; J Rawlings; R H Hunt; D Colin-Jones; G J Milton-Thompson; J J Misiewicz
Journal: Gut Date: 1981-04 Impact factor: 23.059

8. Complete inhibition of food-stimulated gastric acid secretion by combined application of pirenzepine and ranitidine.

Authors: W Londong; V Londong; C Ruthe; P Weizert
Journal: Gut Date: 1981-07 Impact factor: 23.059

Review 9. Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.

Authors: S M Grant; H D Langtry; R N Brogden
Journal: Drugs Date: 1989-06 Impact factor: 9.546

10. The influence of the H-2 receptor antagonist ranitidine on cadaver kidney allograft function.

Authors: T Orłowski; M Smogorzewski
Journal: Int Urol Nephrol Date: 1986 Impact factor: 2.370