Literature DB >> 6101459

Profound analgesic effects of beta-endorphin in man.

T Oyama, T Jin, R Yamaya, N Ling, R Guillemin.   

Abstract

Profound and long-lasting analgesia (mean duration of pain relief 33.4 h, range 22.5--73.5 h) was produced by intrathecal administration of 3 mg synthetic beta-endorphin in all of 14 patients with intractable pain due to disseminated cancer. No respiratory depression, hypotension, hypothermia, or catatonia was observed.

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Year:  1980        PMID： 6101459     DOI： 10.1016/s0140-6736(80)90606-6

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  17 in total

1.  Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man.

Authors:  J I Székely; K Török; I Karczag; J Tolna; M Till
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  Increase of pain threshold by calcitonin during electrical stimulation of the dental pulp. Investigations in healthy volunteers with regard to plasma concentration.

Authors:  K Welzel; D Welzel
Journal:  Schmerz       Date:  1989-09       Impact factor: 1.107

3.  Endogenous monoamine analgesic systems: amitriptyline in painful diabetic neuropathy.

Authors:  M B Max
Journal:  Anesth Prog       Date:  1987-07

Review 4.  Intraspinal opioids: implications for monitoring. Monitoring in the intensive care unit is essential.

Authors:  R F LaPorta; M D Johnson
Journal:  J Clin Monit       Date:  1989-07

5.  Effects of aspirin, naloxone and placebo.

Authors:  A A Mewa; D Rosenbloom; E M Grace; P Brooks; N Bellamy; C Denko; G Norman; W W Buchanan
Journal:  Clin Rheumatol       Date:  1987-12       Impact factor: 2.980

6.  Epidural beta-endorphin in treatment of pain.

Authors:  T Oyama; S Fukushi; T Jin
Journal:  Can Anaesth Soc J       Date:  1982-01

Review 7.  Enkephalins and Endorphins. Clinical, pharmacological and therapeutic implications.

Authors:  D L Copolov; R D Helme
Journal:  Drugs       Date:  1983-12       Impact factor: 9.546

8.  Intrathecal morphine: naloxone reverses respiratory depression but not analgesia.

Authors:  R D Jones; J G Jones
Journal:  Br Med J       Date:  1980-09-06

9.  beta-Endorphin: characteristics of binding sites in rabbit spinal cord.

Authors:  P Ferrara; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

10.  Opioid-receptor antagonism increases pain and decreases pleasure in obese and non-obese individuals.

Authors:  Rebecca C Price; Nicolas V Christou; Steven B Backman; Laura Stone; Petra Schweinhardt
Journal:  Psychopharmacology (Berl)       Date:  2016-09-22       Impact factor: 4.530
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